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Continuous Inline Size Monitoring of Low Turbidity Suspensions

The size and size distribution of low turbidity suspensions in various (bio)pharmaceutical products, including liposomes, lipid nanoparticles, recombinant proteins, and antibodies, plays a significant role in their pharmacokinetic and pharmacodynamic profile in vivo. These factors directly influence therapeutic efficacy, immunogenicity, and safety. Consequently, particle size is considered one of the critical quality attributes for such products. ....

Carl Schuurmans , Nick Koumakis , F Hasanzadeh Davarani , Michiel Hermes , Jan Piet Wijgergangs , R Van Tuijn , Yan Wang , Louis Castel , European Journal Of Pharmaceutical Sciences , Research Unit , Pharma Inc , Bas Evers , Rut Besseling , Dynamic Light Scattering , Process Analytical Tools , Spatially Resolved Dynamic Light Scattering , Image Credit , Cumulantz Av , Inline Cumulantz Av , Offline Cumulantz Av , Bovine Serum Albumin , Antonio Costa , Adv Drug Deliv , European Journal , Low Turbidity Suspensions ,