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Tiny target discovered on RNA to short-circuit inflammation

Researchers have discovered a peptide in human RNA that regulates inflammation and may provide a new path for treating diseases such as arthritis and lupus. The team used a screening process based on the powerful gene-editing tool CRISPR to shed light on one of the biggest mysteries about our RNA the molecule responsible for carrying out genetic information contained in our DNA. ....

Sergio Covarrubias , Lisa Sudek , Sol Katzman , Samira Yitiz , Haley Halasz , Eric Malekos , Christy Montano , Developmental Biology Department , National Institute , Proceedings Of The National Academy Sciences , National Institute Of Allergy , National Academy , Susan Carpenter , Sinsheimer Chair , Developmental Biology , General Medical Sciences , Infectious Diseases ,

New study discovers tiny target on RNA to short-circuit inflammation

New study discovers tiny target on RNA to short-circuit inflammation
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

Sol Katzman , Sergio Covarrubias , Haley Halasz , Samira Yitiz , Lisa Sudek , Christy Montano , Eric Malekos , Carpenter Lab , Proceedings Of The National Academy Sciences , Developmental Biology Department , National Academy , Susan Carpenter , Sinsheimer Chair , Developmental Biology ,

Eliminating RNA-binding protein improves survival in aggressive leukemia


Scientists find that removing IGF2BP3 selectively targets cancer cells while leaving healthy cells alone
UCLA Broad Stem Cell Research Center
Dr. Dinesh Rao and his colleagues had previously identified the IGF2BP3 protein as a factor in driving the development of leukemia through its regulation of RNA messages.
Denise Heady |
July 28, 2021
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.
The research, published today in the journal Leukemia, could aid in the development of targeted therapies for cancers that have high levels of the RNA-binding protein IGF2BP3 especially acute lymphoblastic and myeloid leukemias that are characterized by chromosomal rearrangements in the mixed lineage leukemia (MLL) gene. ....

Jeremy Sanford , Jennifer King , Jaspal Bassi , Jolene Draper , Tiffany Tran , Dinesh Rao , Sol Katzman , Oscar Silva , Amit Jaiswal , Neha Nibber , Julia Philipp , Jayanth Palanichamy , Tasha Lin , Stem Cell Research , David Geffen School Of Medicine , Jonsson Cancer Center , National Institutes Of Health , Jonsson Comprehensive Cancer Center , Stanford University , Edythe Broad Center , Comprehensive Cancer , David Geffen School , Regenerative Medicine , Stem Cell , May Paing , National Institutes ,

Removing RNA-binding protein in subtype of leukemia can help to slow the cancer's development


Removing RNA-binding protein in subtype of leukemia can help to slow the cancer s development
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.
The research, published in the journal Leukemia, could aid in the development of targeted therapies for cancers that have high levels of the RNA-binding protein IGF2BP3 -; especially acute lymphoblastic and myeloid leukemias that are characterized by chromosomal rearrangements in the mixed lineage leukemia (MLL) gene. ....

Jeremy Sanford , Jennifer King , Jaspal Bassi , Jolene Draper , Tiffany Tran , Dinesh Rao , Emily Henderson , Sol Katzman , Oscar Silva , Amit Jaiswal , Neha Nibber , Julia Philipp , Jayanth Palanichamy , Tasha Lin , Stem Cell Research , David Geffen School Of Medicine , Jonsson Cancer Center , National Institutes Of Health , Jonsson Comprehensive Cancer Center , Stanford University , Edythe Broad Center , Comprehensive Cancer , David Geffen School , Regenerative Medicine , Stem Cell , May Paing ,