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Molecular detection platform provides new insights into gene medicine manufacturing

Molecular detection platform provides new insights into gene medicine manufacturing
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Molecular detection platform provides new insights into gene medicine manufacturing

Breakthrough medical technology like mRNA vaccines rely on tiny nanoparticles to deliver medicine to cells. A new device will help drug manufacturers and evaluators like the FDA more precisely measure genetic payloads to evaluate drug effectiveness.

iECURE Partners to Develop Next-Generation Liver-Targeted Lipid Nanoparticles with University of Pennsylvania

New microfluidic device delivers mRNA nanoparticles a hundred times faster

With a ‘liquid assembly line,’ Penn researchers have produced mRNA-delivering-nanoparticles significantly faster than standard microfluidic technologies. The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is the ability to package those sequences into the lipid nanoparticles that deliver them into cells. The researchers’ new platform technology, called Very Large Scale Microfluidic Integration, allows tens of thousands of microfluidic units to be incorporated into a single three-dimensionally etched silicon-and-glass wafer. (Image: Penn Engineering Today)

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