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Background Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.

Objectives The main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular inflammation in PsA.

Methods We included a total of 75 PsA patients with active peripheral arthritis (defined as ≥2 tender and swollen joints) from an ongoing clinical trial (EudraCT 2017-003900-28) and a retrospective group of 40 controls diagnosed with melanoma, without distant metastases and not receiving immunotherapy. The main outcome measure was aortic vascular inflammation which was measured on PET/CT scans using target-to-background ratios. Clinical disease activity in PsA was assessed with ....

Sina Fadaei , Nanette Vincken , Sarita Hartgring , Frank Perton , Anne Karien Marijnissen , Karin Schrijvers , European Association Of Nuclear Medicine Research , University Medical Center , Research Ethics Committee In Utrecht , Ethics Committee , University Medical Center Utrecht , European Association , Nuclear Medicine Research , Leeds Enthesitis Index , Disease Activity , Psoriatic Arthritis , Medical Research Ethics Committee , Medical Ethics Committee , Ria Boot ,