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Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls

Background Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state.

Objectives The main objective of this study was to investigate the difference in vascular inflammation, measured with 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT), in PsA patients and controls. We conducted a secondary analysis to assess the association between clinical parameters of disease activity with vascular inflammation in PsA.

Methods We included a total of 75 PsA patients with active peripheral arthritis (defined as ≥2 tender and swollen joints) from an ongoing clinical trial (EudraCT 2017-003900-28) and a retrospective group of 40 controls diagnosed with melanoma, without distant metastases and not receiving immunotherapy. The main outcome measure was aortic vascular inflammation which was measured on PET/CT scans using target-to-background ratios. Clinical disease activity in PsA was assessed with ....

Sina Fadaei , Nanette Vincken , Sarita Hartgring , Frank Perton , Anne Karien Marijnissen , Karin Schrijvers , European Association Of Nuclear Medicine Research , University Medical Center , Research Ethics Committee In Utrecht , Ethics Committee , University Medical Center Utrecht , European Association , Nuclear Medicine Research , Leeds Enthesitis Index , Disease Activity , Psoriatic Arthritis , Medical Research Ethics Committee , Medical Ethics Committee , Ria Boot ,

$3M Grant Secured for Sector-First in Indigenous Health Research

$3M Grant Secured for Sector-First in Indigenous Health Research
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Paul Stewart , Sharon Claydon , Mark Butler , Michelle Kennedy , Lowitja Institute , Research Ethics Committee , Government National Critical Research Infrastructure , Nequity In Health , National Health , Research Future Fund , University Of Newcastle , National Aboriginal , Productivity Commission , Research Council , Wollotuka Institute , Torres Strait Islander Health , Hunter Medical Research Institute , Research Program , Early Career Research , Hunter New England Health , First Nations , Assoc Professor Michelle Kennedy , Medical Research Future Fund , Federal Government , National Critical Research Infrastructure , Assistant Dean Indigenous Strategy ,

Multi-drug resistant tuberculosis in TB patients

This study showed a prevalence of MDR-TB among pulmonary TB patients, which is similar to some of the eastern African countries. ....

World Health Organization , Al Qahirah , Democratic Republic Of The Congo , Saudi Arabia , Ministry Of Health , Republic Of , South Africa , Benadir Region , Liaoning Province , Russian Federation , Addis Ababa , Statistical Package For Social Sciences , Research Hospital , Forlanini Or Laserreto Tb Center , Ghana National , Democratic Republic , East Africa , Banadir Region , Gene Xpert , Drug Resistant Center , Statistical Package , Social Sciences , Medical Research Ethics Committee , Somali Ministry , Rifampicin Resistant , All Pulmonary ,

Glucocorticoids for the treatment of SJS/TEN syndrome

Summarizing the clinical characteristics of patients with SJS/TEN syndrome and analyzing the efficacy and safety of systemic glucocorticoid therapy ....

United States , Research Objectives , University Third Hospital , Peking University Third Hospital , Medical Research Ethics Committee , Toxic Epidermal Necrosis , General Data , Suspected Allergenic , Nexpected Number , Actual Number , Prognosis Related ,

Algernon Pharmaceuticals Receives Approval for Groundbreaking Phase 1 DMT Human Stroke Study | Comunicados | Edición USA

Algernon Pharmaceuticals Receives Approval for Groundbreaking Phase 1 DMT Human Stroke Study | Comunicados | Edición USA
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United States , United Kingdom , British Columbia , Christopherj Moreau , David Nutt , Research Ethics Committee , University Of New Mexico , Algernon Pharmaceuticals Receives Approval For Groundbreaking Phase , Algernon Pharmaceuticals , Professor Of Neuropsychopharmacology At Imperial College London , Constraint Induced Movement Therapy , Leiden University , Algernon Pharmaceuticals Inc , Centre For Human Drug Research , Leiden University Medical Center , Company Or Algernon , Algernon Pharmaceuticals Receives Approval , Groundbreaking Phase , Stichting Beoordeling Ethiek Biomedisch Onderzoek , Medical Research Ethics Committee , Human Drug Research , Rick Strassman , New Mexico , Imperial College London , Leiden Bio Science Park , Constraint Induced Movement ,