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Latin American and Caribbean research contributions to tackle challenges posed by brain diseases


Latin American and Caribbean research contributions to tackle challenges posed by brain diseases
Every year there are nearly ten million new cases of dementia globally, of which Alzheimer s Disease (AD) is the most common form, accounting for around 60-70% of cases. This special supplement, published in the
Journal of Alzheimer s Disease, focuses on the challenges posed by brain disease and presents significant research contributions from Latin America and the Caribbean that address these challenges to help improve the lives of individuals with AD.
AD is a complex, multifactorial neurodegenerative disorder that represents a major and increasing global health challenge. Neuroscience is making strides in unraveling the brain s secrets through translational research and drug discovery in order to improve the lives of individuals with a wide variety of neurological and psychiatric disorders such as AD, Parkinson s disease, schizophrenia, depression, traumatic brain injury ....

United States , Mexico City , Distrito Federal , Alta Tecnolog , Gabrielle Britton , Carold Sanmart , Emily Henderson , Farmaciay Bioqu , Carlos Velez Pardo , Luisa Rocha , Ks Jagannatha Rao , Neuroscience Research Group , University Of Chile , School Of Biotechnology , Department Of Pharmacobiology , Department Of Neurology , University Of Antioquia Ude , School Of Medical Technology , Research Institute , Latin America , Centro De Neurociencia , Instituto De Investigaciones Cient , Servicios De Alta Tecnolog , Sistema Nacional De Investigaci , Latin American , Guest Editor Gabrielle Britton ,

Brain's Lymphatic System Tied to Alzheimer's Symptoms in Mice


SANDRO DA MESQUITA
Adamaged drainage system in the brain might be behind the spotty performance of some Alzheimer’s therapies, according to a study published April 28 in
Nature. Mice modeling the neurodegenerative disorder that received plaque-busting antibodies along with a treatment to stimulate the growth of lymphatic vessels in the brain saw many of their symptoms reversed. Mice with damaged lymphatics, on the other hand, didn’t respond as well to the antibodies. This suggests that dysfunctional lymphatics might hinder the performance of antibody-based immunotherapy, an approach that has had mixed results in clinical trials among Alzheimer’s patients. 
“Whenever a paper provides us with a novel way to look at Alzheimer’s, such as this one does . . . it opens up a world of possibilities,” says Gabrielle Britton, a neuroscientist at the Instituto de Investigaciones Científicas y Servicios de Alta Tecnología in Panama who was not involved in the resear ....

Stanley Rockson , Alta Tecnolog , Jonathan Kipnis , Gabrielle Britton , Washington University School Of Medicine , Stanford University , Instituto De Investigaciones Cient , Servicios De Alta Tecnolog , Washington University School , Immune Cells Reverses Aging , Presents Data , ஜொனாதன் கிப்னிச் , கேப்ரியல் பிரிட்டன் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஸ்டான்போர்ட் பல்கலைக்கழகம் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , ப்ரெஸெஂட்ஸ் தகவல்கள் ,