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CSPAN2 Key Capitol Hill Hearings December 13, 2014

Englander to serve with him in the United States senate. And while it is not the most, sometimes you feel like youre in the graveyard shift on a friday night presiding over the senate. I must tell him after decades here, it is extremely important to have somebody of his integrity, his ability, his competence, his experience presiding over the senate should make every senator, republican and democratic, proud. Mr. President , after latenight thee theatrics house yesterday i hope well soon vote on the spending bill. I support this comprehensive spending package. Chairwoman mikulski has done an outstanding job. She has been a giant of the appropriations process. She should be congratulated for her perseverance in bringing us to this point right now. Now, mr. President , i spoke yesterday about the funds included in the bill for the state department and foreign operations. I commended members of my office who worked so hard on that. We ....

United States , New Mexico , District Of Columbia , South Carolina , New York , Lake Champlain , Canada General , United Kingdom , Delaware State University , South Dakota , Bob Byrd , Saxby Chambliss , John Mccain Angus King , Francis Collins , Paul Sarbanes , John Thune , Mike Johanns , David Cameron , Nancy Kassebaum , Mary Landrieu , Los Angeles , Chris Coons , Tom Coburn , Sam Nunn , Kay Bailey Hutchinson , Carl Levin ,

Call for Applications: IBS Director position of "Center for Soft and Living Matter" job with Institute for Basic Science(IBS)

Call for Applications: IBS Director position of “Center for Soft and Living Matter” job in South Korea (KR) with Institute for Basic Science(IBS). Apply Today. ....

South Korea , Research Review Committee , Science Research Programs , Ulsan National Institute Of Science , Research Centers , Head Of The Research Evaluation Team , Institute For Basic Science , National Research Foundation Of Korea , Max Planck Institute , Basic Science , Zone Director , Ulsan National Institute , Professor Steve , Living Matter , Scientific Advisory Board , Associate Director , National Research Foundation , Basic Science Research Programs , Park Gi Hoon , Research Evaluation Team ,

2022 Call for Applications: IBS Directors and Chief Investigators job with Institute for Basic Science(IBS)

2022 Call for Applications: IBS Directors and Chief Investigators job in South Korea (KR) with Institute for Basic Science(IBS). Apply Today. ....

Kyongsang Bukto , South Korea , Kwangju Gwangyoksi , Daedeok Innopolis , Research Review Committee , Research Centers , Hq Centers , Neuroscience Imaging Research , Science Research Programs , Gwangju Institute Of Science , Ulsan National Institute Of Science , Campus Center , National Research Foundation Of Korea , Ci Research Groups , Daegu Gyeongbuk Institute Of Science , Pohang University Of Science , Research Areas , Institute For Basic Science , Candidates For Centers , Search Committee , Campus Centers , Korea Advanced Institute Of Science , Max Planck Institute , Basic Science , Chief Investigator , Associate Director ,

Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

Abstract
Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to ....

United States , Soult Ukpyolsi , South Korea , Castillay Leóp , Republic Of Korea , Takara Bio , Exosomes Exos , Leica Biosystems , Bioanalyzer Santa Clara , Analyte Elisarray , Exos Msc , Korea Basic Science Institute National Research Facilities , Younglin Co , Science Research Programs , Korea Basic Science Institute , Agilent Technologies , National Research Foundation , Sungkyunkwan University , Central Lab Animal Inc , Ministry Of Health Welfare , Exostemtech Inc , Aldrich Co , Ministry Of Education , Equipment Center , Hyclone Laboratories Inc , Spectrum Laboratories Inc ,