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Abstract
Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to ....

United States , Soult Ukpyolsi , South Korea , Castillay Leóp , Republic Of Korea , Takara Bio , Exosomes Exos , Leica Biosystems , Bioanalyzer Santa Clara , Analyte Elisarray , Exos Msc , Korea Basic Science Institute National Research Facilities , Younglin Co , Science Research Programs , Korea Basic Science Institute , Agilent Technologies , National Research Foundation , Sungkyunkwan University , Central Lab Animal Inc , Ministry Of Health Welfare , Exostemtech Inc , Aldrich Co , Ministry Of Education , Equipment Center , Hyclone Laboratories Inc , Spectrum Laboratories Inc ,