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Malaria - The Lancet

Malaria - The Lancet
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

Jawa Timur , Nigeria General , Jawa Barat , East Sepik , Papua New Guinea , Republic Of , A Ramawt , Eastern Highlands , Jawa Tengah , Indonesia General , Region Du Centre , Burkina Faso , Ta Izz , North West Frontier , Nusa Tenggara Timur , East Sepik Province , Papua New Guinean , Abbasher Hussien Mohamed Ahmed , Semin Perinatol , Kayin Karen , J Clin Microbiol , Milner Jr , Nat Microbiol , Patrick Gorres , Trop Med Int Health , Lancet Child Adolesc Health ,

Fapon, LASCCO, Abionic Formed Strategic Collaboration for PSP Sepsis Diagnosis in China

Fapon, LASCCO, Abionic Formed Strategic Collaboration for PSP Sepsis Diagnosis in China
finanznachrichten.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from finanznachrichten.de Daily Mail and Mail on Sunday newspapers.

United States , Linkedin Fapon , Prnewswire Fapon , Indiens Wirtschaft , Ihre Chancen , Vitro Diagnostic Medical Devices , Time Point , Sepsis Detection , Different Sepsis Definitions , Severely Burned Patients , Their Accompanying Time Course , Stone Protein Predicts Sepsis , Severely Burned Patients Irrespective , Trauma Severity , Monocentric Observational , Pancreatic Stone Protein , Subsequent Surgery , Scare Med , Swiss Medtech Award , Der Indien , Die Highlights ,

EFFORT Protein trial: questions remain – Authors' reply

EFFORT Protein trial: questions remain – Authors' reply
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United States , G Jan Zijlstra , American Society For Parenteral , Society Of Critical Care Medicine , Scare Med , Critical Care Medicine , American Society , Enteral Nutrition ,

The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action

The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

Noord Holland , Noord Brabant , South Africa , United Kingdom , New York , United States , New Zealand , Schleswig Holstein , Uttar Pradesh , France General , Nordrhein Westfalen , Jammu And Kashmir , South Korea , Wei Ming , Andhra Pradesh , Eastern Cape , Health Administration , Al Qalyubiyah , Cardiovasc Diabetol , Ben Khelil , Sithy Athiya Munavarah , Hinkle Jr , Ben Ahmed , Cardiovasc Disord , Acta Anaesthesiol Scand , Perazzolo Marra ,

KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming

Many cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells1. Here we demonstrate a different scenario: expression of KRAS(G12D) in differentiated AT1 cells reprograms them slowly and asynchronously back into AT2 stem cells that go on to generate indolent tumours. Like human lepidic adenocarcinoma, the tumour cells slowly spread along alveolar walls in a non-destructive manner and have low ERK activity. We find that AT1 and AT2 cells act as distinct cells of origin and manifest divergent responses to concomitant WNT activation and KRAS(G12D) induction, which accelerates AT2-derived but inhibits AT1-derived adenoma proliferation. Augmentation of ERK activity in KRAS(G12D)-induced AT1 cells increases transformation efficiency, proliferation and progression from lepidic to mixed tumour histology. Overall, we have identified a new cell of or ....

United States , Cancer Biol , American Thoracic , European Respiratory Society , Single Cell Wnt , Stem Cell , Cell Biol , Scare Med , Cancer Staging Project , Lung Cancer , Lung Cancer Res , International Association , Lung Cancer Pathology , Genes Dev , Nucleic Acids Res ,