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Membrane around tumors may be key to preventing metastasis


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Image: Jose-Luis Olivares, MIT, with cell images courtesy of the researchers
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For cancer cells to metastasize, they must first break free of a tumor’s own defenses. Most tumors are sheathed in a protective “basement” membrane a thin, pliable film that holds cancer cells in place as they grow and divide. Before spreading to other parts of the body, the cells must breach the basement membrane, a material that itself has been tricky for scientists to characterize.
Now MIT engineers have probed the basement membrane of breast cancer tumors and found that the seemingly delicate coating is as tough as plastic wrap, yet surprisingly elastic like a party balloon, able to inflate to twice its original size. ....

United States , Shengqiang Cai , Yue Zheng , Aming Guo , Alfred Sloan Foundation , National Cancer Institute , Proceedings Of The National Academy Sciences , University Of California At Santa Diego , National Academy , Beijing Normal University , Santa Diego , National Cancer , Mit Meche , Basement Membrane , Cancer Metastasis , Tumor Growth , ஒன்றுபட்டது மாநிலங்களில் , யூஎ ஜெங் , மிங் கூவோ , ஆல்ஃபிரட் ஸ்லோன் அடித்தளம் , தேசிய புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா இல் சாந்தா டியாகோ , தேசிய கலைக்கழகம் , பெய்ஜிங் சாதாரண பல்கலைக்கழகம் , சாந்தா டியாகோ , தேசிய புற்றுநோய் ,