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Study: Membrane around tumors may prevent metastasis shanghainews.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from shanghainews.net Daily Mail and Mail on Sunday newspapers.
Could Surprising Basement Membrane Property Be Harnessed to Constrain Tumors and Prevent Metastasis? March 10, 2021 Source: Christoph Burgstedt/Science Photo Library/Getty Images Studies by scientists at Massachusetts Institute of Technology (MIT), Beijing Normal University, and the University of California, San Diego (UCSD) have generated new insights into the elastic properties of the basement membrane (BM) that sheaths breast cancer tumors, which could feasibly lead to new strategies for preventing tumor metastasis. Their results, reported in Proceedings of the National Academy of Sciences ( PNAS), demonstrated that while this basement membrane is elastic, it also become stiffer as it expands. The team suggested that this property may help basement membranes control how tumors grow, and might also be harnessed to prevent tumor cells from breaking out and spreading to other sites. ....
For cancer cells to metastasize, they must first break free of a tumor's own defenses. Most tumors are sheathed in a protective "basement" membrane a thin, pliable film that holds cancer cells in place as they grow and divide. ....
Credits: Image: Jose-Luis Olivares, MIT, with cell images courtesy of the researchers Previous image Next image For cancer cells to metastasize, they must first break free of a tumor’s own defenses. Most tumors are sheathed in a protective “basement” membrane a thin, pliable film that holds cancer cells in place as they grow and divide. Before spreading to other parts of the body, the cells must breach the basement membrane, a material that itself has been tricky for scientists to characterize. Now MIT engineers have probed the basement membrane of breast cancer tumors and found that the seemingly delicate coating is as tough as plastic wrap, yet surprisingly elastic like a party balloon, able to inflate to twice its original size. ....