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Reawakened immune cells attack cells tied to diseases of aging


A natural killer cell
NIAID
Scientists have started to test whether natural killer, or NK, cells can be trained to go after hard-to-cure blood cancers in human patients. But making these sentinels of the innate immune system a potential boon to human health spans might be simpler: Rather than needing to be genetically engineered or primed with synthetic antibodies, they just need to be turned on.
In mice, researchers reported on Monday in the journal Med, activating NKT cells can eliminate the senescent cells partly responsible for many diseases of aging. If the results hold up, they could offer a promising alternative to “senolytics” experimental drugs that destroy these zombified cells that pile up and pollute your tissues as you get older. Although dozens of such drugs have postponed or even reversed diseases of aging in mouse experiments, clinical trials have thus far underwhelmed. ....

Mayo Kirkland , Robin Mansukhani , James Kirkland , Longevity Fund , Laura Deming Longevity Fund , University Of California San Francisco , Elysium Health , Mayo Clinic , Anil Bhushan , California San , Kirin Brewery , Deciduous Therapeutics , Laura Deming , Unity Biotechnology , ஜேம்ஸ் கர்க்‌ல்யாஂட் , நீண்ட ஆயுள் நிதி , லாரா டெமிங் நீண்ட ஆயுள் நிதி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , மயோ சிகிச்சையகம் , அனில் பூஷன் , கலிஃபோர்னியா சான் , கிரீன் மதுபானம் , லாரா டெமிங் , ஒற்றுமை உயிரி தொழில்நுட்பவியல் ,