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Seladelpar Reduces Serum IL-31, Improves Pruritus in Patients with Primary Biliary Cholangitis

The post-hoc analysis of the phase 3 ENHANCE study provides the first published evidence of a correlation between decreases in IL-31, bile acids, and pruritus symptoms in PBC following treatment with an investigational agent. ....

Researchgate Andreas Kremer , Cymabay Seladelpar , Drug Administration , University Hospital Zurich , Andreas Kremer , Bay Therapeutics , Breakthrough Therapy Designation , New Drug Application , Priority Review , Pruritis Improvement , Primary Biliary Cholangitis , Hoc Analysis , Primary Biliary , Interleukin 31 , Il 31 , Bile Acid ,

Andreas Kremer, MD, PhD, MHBA: Seladelpar for the Treatment of PBC

Kremer discusses new ad hoc findings from the phase 3 ENHANCE trial showing seladelpar's unique effect on pruritus in patients with PBC. ....

United States , British Columbia , Researchgate Andreas Kremer , Andreas Kremer , University Hospital Zurich , American College Of Gastroenterology , American College , Scientific Meeting , Primary Biliary Cholangitis , Phase 3 , Acg 2023 ,