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Seladelpar Reduces Serum IL-31, Improves Pruritus in Patients with Primary Biliary Cholangitis

The post-hoc analysis of the phase 3 ENHANCE study provides the first published evidence of a correlation between decreases in IL-31, bile acids, and pruritus symptoms in PBC following treatment with an investigational agent.

Researchgate andreas kremerCymabay seladelparDrug administrationUniversity hospital zurichAndreas kremerBay therapeuticsBreakthrough therapy designationNew drug applicationPriority reviewPruritis improvementPrimary biliary cholangitisHoc analysisPrimary biliaryInterleukin 31Il 31Bile acid

Hepatology Month in Review: October 2023

Our October 2023 hepatology month in review features phase 2/3 data, updates in the hepatology pipeline, and other top news.

United statesAndreas kremerMazen noureddinUniversity hospital zurichHouston research instituteTop newsNonalcoholic fatty liver diseaseAlcohol associated liver diseaseHepatitisc virusLiver fatAlagille syndromeDaa therapyDirect acting antiviralsLiver fibrosis

Andreas Kremer, MD, PhD, MHBA: Seladelpar for the Treatment of PBC

Kremer discusses new ad hoc findings from the phase 3 ENHANCE trial showing seladelpar's unique effect on pruritus in patients with PBC.

United statesBritish columbiaResearchgate andreas kremerAndreas kremerUniversity hospital zurichAmerican college of gastroenterologyAmerican collegeScientific meetingPrimary biliary cholangitisPhase 3Acg 2023

CymaBay Presents Results on the Potential of Seladelpar in Treatment of Patients with Primary Biliary Cholangitis at ACG 2023

CymaBay Presents Results on the Potential of Seladelpar in Treatment of Patients with Primary Biliary Cholangitis at ACG 2023
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United kingdomBritish columbiaHans vitzthumAndreas kremerGideon hirschfieldCharles mcwherterTheresa dolgeAndrease kremerAmerican college of gastroenterologyEuropean medicines agencyCymabay therapeutics incExchange commissionUniversity of zurichLifesci advisorsInternational awardInternational liver congress

Ask me about PBC campaign calls on patients to speak up for rare liver disease

Ask me about PBC campaign calls on patients to speak up for rare liver disease
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United statesTerry hornerBettinae hansenAndreas kremerJohn puisisGideon hirschfieldRobert stottBysara kellnerInternational primary biliary cholangitis dayIntercept pharmaceuticalsAmerican liver foundationUniversity of miami miller school medicineUniversity of torontoPrimary biliary cholangitis dayCymabay therapeuticsClinical gastroenterology