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Depression and Stress Could Dampen Efficacy of COVID-19 Vaccines: Interventions and Health Behavior Changes Could Boost Immunity

Summary: Health behaviors and emotional stressors can alter the body’s ability to develop an immune response to vaccines, including potentially the new COVID-19 vaccines. Simple interventions, including exercising and getting a good night’s sleep in the 24 hours before vaccination, may maximize the vaccine’s initial effectiveness. Decades of research show that depression, stress, loneliness, and poor health behaviors can weaken the body’s immune system and lower the effectiveness of certain vaccines. A new report accepted for publication in Perspectives on Psychological Science suggests that the same may be true for the new COVID-19 vaccines that are in development and the early stages of global distribution. Fortunately, it may be possible to reduce these negative effects with simple steps like exercise and sleep.

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