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 E-Mail IMAGE: Graphic illustration of the work: DNA-programmed affinity labelling (DPAL) enables the direct screening of DNA-encoded chemical libraries (DELs) against membrane protein targets on live cells to create novel drug discovery. view more  Credit: The University of Hong Kong A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells. Membrane proteins play important roles in biology, and many of them are high-value targets that are being intensively pursued in the pharmaceutical industry. The method developed by Dr Li s team provides an efficient way to discover novel ligands and inhibitors against membrane proteins, which remain largely intract

Hong kongXiaoyu liUniversity of hong kongHong kong generalBryan caoYiran huangYizhou liProfessor of research division for chemistrySecond military medical universityCentre for panoromic sciencesNational natural science foundation of chinaNature research chemistry communityLaboratory for synthetic chemistryNature publishing groupTechnology commission of hong kongResearch grants council of hong kong