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New molecular glue degraders could help targe

<p>Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis. Scientists think that with the help of “matchmaker” molecules called molecular glue degraders, this machinery could be hijacked to control proteins involved in diseases like cancer. But only a few of these glue degraders have been discovered so far—and mostly by chance.</p>

<p>Zuzanna Kozicka, as a Ph.D. student at Friedrich Miescher Institute in Basel, Switzerland, embarked on a deliberate search for these glues with her team and identified a novel class of molecular glue degraders with more than 40 chemically diverse members. Kozicka, who is now a postdoctoral fellow at the Dana Farber Cancer Institute, also took a closer look at the crystal structures of the complexes that these molecules induce to glean clues about how they carry out their matchmaking services. She is the grand prize winner in molecular medicine of the & ....

San Diego , United States , Scripps Institution Of Oceanography , California Institute Of Technology , Rachel Kratofil , Zuzanna Kozicka , Jessica Kendall , Olli Kallioniemi , University Of Victoria , Friedrich Miescher Institute In Basel , Dana Farber Cancer Institute , University Of Tokyo , University Of Calgary , York University Grossman School Of Medicine , University Of California , Friedrich Miescher Institute , Scilifelab Prize , Young Scientists , Professor Olli Kallioniemi , New York University Grossman School , California Institute , Science Postdoctoral Fellow , Scripps Institution ,

New Molecular Glue Degraders Target Troublesome Proteins

New Molecular Glue Degraders Target Troublesome Proteins
aaas.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from aaas.org Daily Mail and Mail on Sunday newspapers.

Scripps Institution Of Oceanography , United States , San Diego , California Institute Of Technology , Olli Kallioniemi , Rachel Kratofil , Valda Vinson , Zuzanna Kozicka , Jessica Kendall , University Of Victoria , University Of Tokyo , Friedrich Miescher Institute In Basel , Dana Farber Cancer Institute , York University Grossman School Of Medicine , University Of Calgary , University Of California , Friedrich Miescher Institute , Scilifelab Prize , Executive Editor Valda , Dana Farber Cancer , Young Scientists , Scilifelab Director Olli , New York University Grossman School , California Institute , Scripps Institution ,

New evidence shows white blood cells can repair or fight during an infection

New evidence shows white blood cells can repair or fight during an infection
thegauntlet.ca - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thegauntlet.ca Daily Mail and Mail on Sunday newspapers.

Rachel Kratofil , Ramiro Bustamante Torres , York University Langone Health , Cumming School Of Medicine , Snyder Institute For Chronic Diseases , Snyder Institute , University Of Calgary , Kubes Lab , Chronic Diseases , Cumming School , New York University , Langone Health ,

The Immune System's Weirdest Weapon

The Immune System's Weirdest Weapon
msn.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from msn.com Daily Mail and Mail on Sunday newspapers.

United States , Region Flamande , Rachel Kratofil , Ed Reschke Getty , Shuichi Takayama , Denisa Wagner , Anna Huttenlocher , Kim Martinod , Paul Kubes , University Of Toronto , University Of Wisconsin At Madison , University Of Calgary , University Of Utah , Con Yost , Georgia Tech , Nades Palaniyar , ஒன்றுபட்டது மாநிலங்களில் , பால் க்யூப்ஸ் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , பல்கலைக்கழகம் ஆஃப் விஸ்கான்சின் இல் மாடிசன் , பல்கலைக்கழகம் ஆஃப் கல்கரி , பல்கலைக்கழகம் ஆஃப் உட்டா , ஏமாற்றுபவன் யொஸ்ட் , ஜார்ஜியா தொழில்நுட்பம் ,

The Super-Soldier Cells Hiding in Your Pus

The Super-Soldier Cells Hiding in Your Pus
theatlantic.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theatlantic.com Daily Mail and Mail on Sunday newspapers.

United States , Region Flamande , Rachel Kratofil , Shuichi Takayama , Denisa Wagner , Anna Huttenlocher , Kim Martinod , Paul Kubes , University Of Toronto , University Of Wisconsin At Madison , University Of Calgary , University Of Utah , Con Yost , Georgia Tech , Nades Palaniyar , ஒன்றுபட்டது மாநிலங்களில் , பால் க்யூப்ஸ் , பல்கலைக்கழகம் ஆஃப் டொராண்டோ , பல்கலைக்கழகம் ஆஃப் விஸ்கான்சின் இல் மாடிசன் , பல்கலைக்கழகம் ஆஃப் கல்கரி , பல்கலைக்கழகம் ஆஃப் உட்டா , ஏமாற்றுபவன் யொஸ்ட் , ஜார்ஜியா தொழில்நுட்பம் ,