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New molecular glue degraders could help targe

<p>Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis. Scientists think that with the help of “matchmaker” molecules called molecular glue degraders, this machinery could be hijacked to control proteins involved in diseases like cancer. But only a few of these glue degraders have been discovered so far—and mostly by chance.</p>

<p>Zuzanna Kozicka, as a Ph.D. student at Friedrich Miescher Institute in Basel, Switzerland, embarked on a deliberate search for these glues with her team and identified a novel class of molecular glue degraders with more than 40 chemically diverse members. Kozicka, who is now a postdoctoral fellow at the Dana Farber Cancer Institute, also took a closer look at the crystal structures of the complexes that these molecules induce to glean clues about how they carry out their matchmaking services. She is the grand prize winner in molecular medicine of the & ....

San Diego , United States , Scripps Institution Of Oceanography , California Institute Of Technology , Rachel Kratofil , Zuzanna Kozicka , Jessica Kendall , Olli Kallioniemi , University Of Victoria , Friedrich Miescher Institute In Basel , Dana Farber Cancer Institute , University Of Tokyo , University Of Calgary , York University Grossman School Of Medicine , University Of California , Friedrich Miescher Institute , Scilifelab Prize , Young Scientists , Professor Olli Kallioniemi , New York University Grossman School , California Institute , Science Postdoctoral Fellow , Scripps Institution ,

New Molecular Glue Degraders Target Troublesome Proteins

New Molecular Glue Degraders Target Troublesome Proteins
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Scripps Institution Of Oceanography , United States , San Diego , California Institute Of Technology , Olli Kallioniemi , Rachel Kratofil , Valda Vinson , Zuzanna Kozicka , Jessica Kendall , University Of Victoria , University Of Tokyo , Friedrich Miescher Institute In Basel , Dana Farber Cancer Institute , York University Grossman School Of Medicine , University Of Calgary , University Of California , Friedrich Miescher Institute , Scilifelab Prize , Executive Editor Valda , Dana Farber Cancer , Young Scientists , Scilifelab Director Olli , New York University Grossman School , California Institute , Scripps Institution ,

ARTBIO Announces Appointment of Nick Pullen, Ph.D., as Chief Scientific Officer

Management expansion strengthens capabilities in developing new class of alpha radioligand therapies ....

United Kingdom , City Of , Nick Pullen , Emanuele Ostuni , Integrative Sciences At Celgene , University Of Oslo , Prnewswire Artbio Inc , Friedrich Miescher Institute In Basel , University Of Southampton , Head Of Research At Jnana Therapeutics , Chief Scientific , Chief Executive Officer , Senior Vice President , Vice President , Integrative Sciences , Friedrich Miescher Institute ,

ARTBIO Announces Appointment of Nick Pullen, Ph.D., as Chief Scientific Officer

/PRNewswire/ ARTBIO, Inc. (ARTBIO), a clinical-stage radiopharmaceutical company developing a new class of targeted alpha radioligand therapies (ART), today. ....

United Kingdom , City Of , Nick Pullen , Emanuele Ostuni , University Of Southampton , Head Of Research At Jnana Therapeutics , Integrative Sciences At Celgene , University Of Oslo , Prnewswire Artbio Inc , Friedrich Miescher Institute In Basel , Chief Scientific , Chief Executive Officer , Senior Vice President , Vice President , Integrative Sciences , Friedrich Miescher Institute ,

ARTBIO Announces Appointment of Nick Pullen, Ph.D., as Chief Scientific Officer

ARTBIO Announces Appointment of Nick Pullen, Ph.D., as Chief Scientific Officer
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United Kingdom , City Of , Nick Pullen , Emanuele Ostuni , Integrative Sciences At Celgene , Head Of Research At Jnana Therapeutics , Prnewswire Artbio Inc , University Of Southampton , Friedrich Miescher Institute In Basel , University Of Oslo , Chief Scientific , Chief Executive Officer , Senior Vice President , Vice President , Integrative Sciences , Friedrich Miescher Institute ,