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PrEP Implant May Protect Against HIV for a Year

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Pharmacokinetic data indicated that an implant that elutes islatravir, an antiretroviral agent, could protect people at-risk of contracting HIV for at least a year, positioning it as a potential form of pre-exposure prophylaxis (PrEP), researchers reported.
In a trial in which people at low risk of HIV-infection were implanted with three different doses of islatravir, blood levels of islatravir remained well above the level considered sufficient for protection against infection at week 12, according to Randolph Matthews, MD, PhD, a senior scientist at Merck in Kenilworth New Jersey.
The largest dose – 56 mg – was projected to yield adequate islatravir blood levels for almost all individuals for at least 52 weeks, he said in his oral presentation at the virtual Conference on Retroviruses and Opportunistic Infections (CROI). ....

Randolph Matthews , Sharon Hillier , Richard Koup , University Of Pittsburgh School Medicine , National Institute Of Allergy , Kenilworth New , Opportunistic Infections , National Institute , Infectious Diseases , Pittsburgh School , Medpage Today , Human Immunodeficiency Virus Infection , Infectious Disease , Pruritic Disorders , ரேண்டால்ஃப் மேத்யூஸ் , ஷரோன் ஹில்லியர் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , தேசிய நிறுவனம் ஆஃப் ஒவ்வாமை , கெநில்‌வர்த் புதியது , தேசிய நிறுவனம் , தொற்று நோய்கள் , பிட்ஸ்பர்க் பள்ளி , தொற்று நோய் ,

Peanut SLIT Seems Safe, Effective in Toddlers

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Peanut sublingual immunotherapy (SLIT) was associated with significant desensitization in toddlers, ages 1 to 4 years, with no safety issues, a randomized trial showed.
During the placebo-controlled trial, cumulative tolerated dose in the peanut SLIT group increased to 4,333 mg of peanut protein versus 143 mg in the placebo group (
P 0.0001), according to Edwin Kim, MD, of the University of North Carolina Food Allergy Initiative in Chapel Hill.
The treatment effect achieved with peanut SLIT was stronger than that previously reported in studies involving older children and it tended to last longer, Kim said during his presentation at the American Academy of Allergy, Asthma & Immunology virtual meeting. ....

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