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Novartis Pharma AG: Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Trial met both primary and most secondary endpoints, showing iptacopan provided transfusion-free hemoglobin-level increases in vast majority of adult paroxysmal nocturnal hemoglobinuria (PNH) patients

France generalUnited statesRichard jarvisIsabella zinckMichael meoSatoshi sugimotoNicole zinsli sommSamir shahParag mahantiJulie masowSloan simpsonMary carmichaelAnn hematolNovartis institutes for biomedical researchExchange commissionGreater paris university hospital

Iptacopan Resolves Anemia in Phase III Trial for Paroxysmal Nocturnal Hemoglobinuria

Study in ASH Late-Breaking Abstracts session: Iptacopan Resolves Anemia in Phase III Trial for Paroxysmal Nocturnal Hemoglobinuria.

United statesFrance generalAmerican society of hematologyGreater paris university hospitalsProximal complement inhibitorHas superior efficacyIntravenous terminal complement inhibitionCare eculizumabFavorable safetyParoxysmal nocturnal hemoglobinuriaResidual anemiaAmerican societyAnnual meetingPeffault de latourSaint louis hospitalGreater paris university

Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5
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United statesFrance generalGiuseppe moscatiDavid soergelMichael meoPrnewswire novartisJulie masowSloan simpsonAnn hematolMary carmichaelAntonio risitanoNovartis institutes for biomedical researchInterest groupExchange commissionGreater paris university hospitalNovartis pharmaceuticals