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Trial data released for potentially practice-changing PNH medicine

Iptacopan achieved "improvement of anaemia never seen before with anti-C5s” in PNH, showed Novartis data presented at 2023 EBMT.

France generalDavid soergelAntonio risitanoGiuseppe moscatiInterest groupMeeting of the european society for bloodReference centerMetabolism development unit at novartisGreater paris university hospitalEuropean societyMarrow transplantationPeffault de latourSaint louis hospitalGreater paris universityHematopoietic transplant unitAplastic anemia

Novartis Pharma AG: Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Trial met both primary and most secondary endpoints, showing iptacopan provided transfusion-free hemoglobin-level increases in vast majority of adult paroxysmal nocturnal hemoglobinuria (PNH) patients

France generalUnited statesRichard jarvisIsabella zinckMichael meoSatoshi sugimotoNicole zinsli sommSamir shahParag mahantiJulie masowSloan simpsonMary carmichaelAnn hematolNovartis institutes for biomedical researchExchange commissionGreater paris university hospital

Novartis presents pivotal Phase III APPLY-PNH data at ASH demonstrating investigational oral monotherapy iptacopan superiority over anti-C5

Trial met both primary and most secondary endpoints, showing iptacopan provided transfusion-free hemoglobin-level increases in vast majority of adult.

United statesFrance generalPrnewswire novartisExchange commissionGreater paris university hospitalNovartis institutes for biomedical researchAmerican society of hematology annual meeting expositionAmerican societyHematology annual meetingPeffault de latourSaint louis hospitalGreater paris universityNovartis institutesBiomedical researchTherapy designationNovartis pharmaceuticals corporation

Iptacopan Resolves Anemia in Phase III Trial for Paroxysmal Nocturnal Hemoglobinuria

Study in ASH Late-Breaking Abstracts session: Iptacopan Resolves Anemia in Phase III Trial for Paroxysmal Nocturnal Hemoglobinuria.

United statesFrance generalAmerican society of hematologyGreater paris university hospitalsProximal complement inhibitorHas superior efficacyIntravenous terminal complement inhibitionCare eculizumabFavorable safetyParoxysmal nocturnal hemoglobinuriaResidual anemiaAmerican societyAnnual meetingPeffault de latourSaint louis hospitalGreater paris university

Novartis Reports Positive Results Late-Stage Study Of PNH Therapy

Novartis Reports Positive Results Late-Stage Study Of PNH Therapy
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United statesFrance generalGreater paris university hospitalAmerican society of hematology annual meeting expositionAmerican societyHematology annual meetingPeffault de latourSaint louis hospitalGreater paris universityFunctional assessmentChronic illness therapy