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ERG11 Gene of Fluconazole-resistant Candida albicans

Our results showed new mutations in the heme-binding pocket of caCYP51 that explain the resistance to fluconazole exhibited by the Candida isolates. ....

United States , France General , Nordrhein Westfalen , Andhra Pradesh , Nepal General , Candida Agar Chromagar , Clustal Omega , Laboratory Standards Institute , National Center , Protein Data Bank , University Of Nigeria Medical Center , Molecular Evolutionary Genetic Analysis Software , University Of Nigeria Veterinary Teaching Hospital , Plain Language , Nigeria Medical Center , Nigeria Veterinary Teaching Hospital , Sabouraud Dextrose Agar , Chromogenic Agar , Candida Agar , Genomic Lysis Buffer , Lysis Buffer , Wash Buffer , Candida Species , Thermal Cycler , Thermo Fisher Scientific , Zymo Seq ,

[Full text] Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is

XYS Activates the PI3K/Akt Pathway
Network pharmacology suggested that the PI3k/Akt pathway was the main mechanism of action in IS treatment by XYS. Therefore, we evaluated the effect of XYS on the mRNA and protein expression of PI3k and Akt in PC12 cells. OGD/R inhibited mRNA expression of PI3K and Akt significantly in PC12 cells (Figures 9 and 10). Compared with the normal group, although protein expression of PI3K and Akt did not change significantly, phosphorylation of PI3K and Akt was inhibited significantly. Fortunately, XYS therapy could reverse this inhibition. These results indicated that the PI3k/Akt pathway was involved in the anti-IS action of XYS. ....

United States , Oliv Diels , Schwein Ryvarden Gilb , Professor Weiyin Chen Hospital Of Chengdu University , Thermo Fisher , Chengdu University , Beina Chuanglian Biotechnology Research Institute , Beckman Coulter , Interaction Network , Analysis Platform , Pubchem Compound , Chemical Book , Online Mendelian Inheritance , Treatment Targets Database , Protein Database , Search Tool , Discovery Studio , Statistical Computing , Roswell Park Memorial , Grand Island , Annexinv Fluorescein , Cell Counting Kit , Shengon Biotech , Boster Biological , Beijing Bioss Biotechnology , Small Molecule Compounds ,

3D-Printed Models Explain Body's Fight Against COVID-19

David Goodsell/ProteinDatabase, CC BY-SA
Editor’s note: In this interview, Nathan Ahlgren, assistant professor of biology at Clark University, uses 3D-printed models to explain what proteins do in viruses, how they interact with human cells, how the vaccine delivers mRNA into the cell, and how antibodies protect us. This follows an earlier article in which he explained what proteins are and the wide range of functions they have in the body.
What do proteins do in a virus? What else is in a virus?
All of life has proteins. So human cells have proteins, and the same is true for viruses, even though they’re very different from the cells in our body. A virus is made up of two main things – a protein shell and genetic material. ....

Nathan Ahlgren , David Godsell , David Goodsell , Clark University , Protein Database , டேவிட் பொருட்கள் விற்பனை , கிளார்க் பல்கலைக்கழகம் , ப்ரோடீந் தரவுத்தளம் ,