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Soft-landing methods aim to simplify structural biology

Linking mass spectroscopy with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target. Linking mass spectroscopy with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target. ....

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The Protein Structure Prediction Revolution and Its Implications for Medicine: 2023 Albert Lasker Basic Medical Research Award | Health Informatics | JAMA

In this Viewpoint, 2023 Lasker award winners John Jumper and Demis Hassabis describe their invention, the artificial intelligence–based system AlphaFold, which ....

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Research opens up new directions to develop drugs for stopping cytokine storms

Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response. ....

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Switching off cytokine storm

Switching off cytokine storm
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Switching off the cytokine storm

In a new paper published in Science, EMBL Grenoble researchers provide essential insights on the molecular activation of the MAP kinase p38α, the final switch triggering the inflammatory response.
Inflammation is a cellular coping mechanism when confronted with stress, such as an infection. However, too much inflammation can damage the functioning of cells and organs. This is the case with cytokine storms, inflammatory cascades that can lead to severe disease and death, recently highlighted during the COVID-19 pandemic.
These results open up new directions to develop drugs to prevent cytokine storms and to study similar processes in two other families of MAP kinases, involved in cancer and Alzheimer’s disease respectively. ....

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