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Soft-landing methods aim to simplify structural biology

Linking mass spectroscopy with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target. Linking mass spectroscopy with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target. ....

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Molecular firing range allows surprisingly specific bond breaking

At energies equivalent to temperatures of several thousand Kelvin fragmentation is unexpectedly precise ....

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'Splat chemistry' creates substances by chucking molecules at a wall

Anggara et al
Breaking the chemical bonds in large molecules to form a desired substance can be a fiddly task, but simply chucking molecules at a wall can get the job done.
Stephan Rauschenbach at the University of Oxford and his colleagues made the discovery, which they call “splat chemistry”, after accidentally firing a complex molecule called Reichardt’s dye at a copper surface.
The team expected the collision to have enough energy to break all the bonds in the molecule, but that wasn’t the case, says Rauschenbach. “Despite this huge …
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