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Mad2 expression levels with chromosomal abnormalities can be a biomarker for esophageal cancer

A new research paper was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples." ....

Sillarine Kurkalang , Pooja Swargiary , Hughbert Dakhar , Nabamita Boruah , Chongtham Sovachandra Singh , Atanu Banerjee , Anupam Chatterjee , North Eastern Hill University , Assam Royal Global University , Ln Mithila University , University Of Chicago Medicine , University Of Pennsylvania , Chicago Medicine , Nazareth Hospital , Esophageal Cancer , Promoter Region ,

New fluorogenic probe could quickly detect the presence of influenza A virus

The influenza A virus, which is responsible for seasonal flu outbreaks, is also the only influenza virus that has previously caused flu pandemics. ....

Yusuke Sato , Emily Henderson , Tohoku University , Associate Professor , Analytical Chemistry , Promoter Region ,

LncRNA-CCDC144NL-AS1 Promotes Liver Cancer Development


9 Aberrantly expressed CCDC144NL-AS1 was observed in gastric cancer,
9 however, its roles in HCC development and the potential mechanism have not been reported yet. In this study, we investigated the expression pattern of CCDC144NL-AS1 using human HCC tissues, and explored the underlying mechanism from the epigenetic pathway. We also estimated the therapy value of CCDC144NL-AS1 using HCC mouse model. Our study may provide novel therapeutic targets for HCC treatment to improve the prognosis of HCC.
Patients and Methods
Tissue Collection
From April 2014 to December 2015, 135 pairs of HCC tissues and the matched adjacent normal tissues were collected from the Department of Infectious Diseases of the First Affiliated Hospital of Zhengzhou University. Patients who received treatments before or complicated with distant metastasis or other systemic diseases such as diabetes, cardiovascular, or cerebrovascular diseases were excluded from this study. ....

Eteläuomen Läi , United States , Streptavidin Invitrogen , Becton Dickinson , Public Protein Plasmid Library Jiangsu , Tecan Group Ltd , Proteintech Group , Imagej National Institutes Of Health , Cell Signaling Technology , First Affiliated Hospital Of Zhengzhou University , Graphpad Software , Keygen Biotech Co Ltd , Infectious Diseases , First Affiliated Hospital , Ethics Committee , Zhengzhou University , American Type Culture Collection , Modified Eagle , Thermo Fisher Scientific , Transfection Reagent , Plasmid Library , Animal Experiments , Multi Site Directed Mutagenesis Kit , National Institutes , Bio Rad Laboratories , Deep Sequencing ,