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Scientists identify progenitor cells that could revolutionize osteoarthritis treatment

Researchers report that osteoarthritis is caused by the loss of Gremlin 1 (Grem1)-lineage chondrogenic progenitor cells. ....

Nature Communications , Bone Marrow , Joint Pain , Pain Management , Progenitor Cells , Stem Cells ,

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments. ....

Hutchinson Gilford Progeria Syndrome , Scientific Reports , Cell Cycle , Ell Death , Hutchinson Gilford Progeria , N Vitro , Oxidative Stress , Progenitor Cells ,

3D printing crafts cerebral cortex tissues: A breakthrough for brain injury treatment

Researchers utilize 3D printing to craft cerebral cortex tissues with organized neurons, offering potential treatments for brain injuries. This novel technique prints neural progenitors in layer-by-layer sequences, aiming for accurate tissue restoration in damaged brains. ....

Neha Mathur , Peter Porrini Shutterstock , Sophia Coveney , Neha Mathuroct , Nature Communications , Neural Maintenance Medium , Neural Terminal Medium , Polymerase Chain Reaction , Nex Vivo , Ognitive Function , Ene Expression , Growth Factor , Progenitor Cells , Traumatic Brain Injury ,

"From Free Tissue Transfer to Hydrogels: A Brief Review of the Applicat" by Hai Xin, Eva Tomaskovic-Crook et al.

The periosteum is a thin layer of connective tissue covering bone. It is an essential component for bone development and fracture healing. There has been considerable research exploring the application of the periosteum in bone regeneration since the 19th century. An increasing number of studies are focusing on periosteal progenitor cells found within the periosteum and the use of hydrogels as scaffold materials for periosteum engineering and guided bone development. Here, we provide an overview of the research investigating the use of the periosteum for bone repair, with consideration given to the anatomy and function of the periosteum, the importance of the cambium layer, the culture of periosteal progenitor cells, periosteum-induced ossification, periosteal perfusion, periosteum engineering, scaffold vascularization, and hydrogel-based synthetic periostea. ....

3d Printing , Cambium Layer , Progenitor Cells , Ynthetic Periosteum ,

Single-cell screening of cerebral organoids to identify developmental defects in autism

Researchers develop CRISPR-human organoids-single-cell RNA sequencing system to identify developmental brain defects in autism. ....

Yurchanka Siarhei , Simons Foundation Autism Research Initiative , Lysinen Methyltransferase , Ene Expression , Palindromic Repeats , Progenitor Cells , Ibonucleic Acid , Stem Cells ,