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Switching from antiretroviral therapy (ART) containing tenofovir disoproxil fumarate (TDF) to ART containing tenofovir alafenamide (TAF) is associated with increased risk for significant weight increases, obesity, and rising blood lipid levels in people living with HIV. In contrast to most previous studies that were performed among treatment-naive patients, the changes in weight in the present study could not be attributed to better health due to starting HIV treatment as the patients studied were already taking ART with TDF for 6 months or longer. These findings from a cohort study are published in
Annals of Internal Medicine. ....

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