opens in venice later today but are what are the films exciting the critics this year? welcome to our viewers on pbs in america and around the globe. mikhail gorbachev, the last leader of the soviet union, has died at the age of 91. he made it his mission to push for perestroika political and economic reforms to kickstart the russian economy and set the goal for glasnost more openness and transparency in the policies of the state and judicial system. he oversaw enormous changes, namely the break up of the soviet union in 1991, and the end of the cold war. president macron said he was a man of peace. russian president vladimir putin, who had a sharply divergent view of how things should be done, has expressed his deep sympathies . our russia editor steve rosenberg looks back at an historic life. he was the kind of russian leader the world had never seen. mikhail gorbachev smiled, he was relaxed. in the west, he acquired almost pop star status for helping to end the cold
A microfluidic organ chip model of the human blood-brain barrier for development of brain-targeting therapeutics
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Boosting CAR-T cell therapies from under the
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CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team has developed a simple intervention in the form of a biodegradable scaffold material called T-cell enhancing scaffolds (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model.