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Key Element Drives Parkinson's, Cancer, Type 2 Diabetes

Key Element Drives Parkinson's, Cancer, Type 2 Diabetes
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Portia Lombardo , Williamr Brody , Reuben Shaw , Retinopathydiabetesdiabetic Dietotitis Mediadiabetes , Salk Cancer Center , Professor Reuben Shaw , Science Advances , Chien Min Hung , Blood Glucose , Monitoring Of Blood Glucose , Insulin Delivery Devicesdiabetes , போர்ஶிய லோம்பார்டோ , ரூபன் ஷா , சாள்க் புற்றுநோய் மையம் , ப்ரொஃபெஸர் ரூபன் ஷா , சீன் நிமிடம் தொங்கவிடப்பட்டது ,

Parkinson's disease, type 2 diabetes, and cancer share the same pathway, shows study

Parkinson s disease, type 2 diabetes, and cancer share the same pathway, shows study
When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell s most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell.
Now Salk researchers have discovered a direct link between a master sensor of cell stress and Parkin itself. The same pathway is also tied to type 2 diabetes and cancer, which could open a new avenue for treating all three diseases.
Our findings represent the earliest step in Parkin s alarm response that anyone s ever found by a long shot. All the other known biochemical events happen at one hour; we ve now found something that happens within five minutes, says Professor Reuben Shaw, director of the NCI-designated Salk Cancer Center and senior author of the new work, detailed in ....

Portia Lombardo , Williamr Brody , Reuben Shaw , Emily Henderson , Salk Cancer Center , Professor Reuben Shaw , Science Advances , Chien Min Hung , Salk Cancer , போர்ஶிய லோம்பார்டோ , ரூபன் ஷா , எமிலி ஹென்டர்சன் , சாள்க் புற்றுநோய் மையம் , ப்ரொஃபெஸர் ரூபன் ஷா , சீன் நிமிடம் தொங்கவிடப்பட்டது , சாள்க் புற்றுநோய் ,

Parkinson's, cancer, type 2 diabetes share a key element that drives disease

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IMAGE: Parkin protein (green signal) is in a different part of the cell than the mitochondria (red signal) at time 0 (left image) but then co-localizes with the mitochondria after 60.
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Credit: Salk Institute
LA JOLLA (April 7, 2021) When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell s most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell. Now Salk researchers have discovered a direct link between a master sensor of cell stress and Parkin itself. The same pathway is also tied to type 2 diabetes and cancer, which could open a new avenue for treating all three diseases. ....

Portia Lombardo , Williamr Brody , Reuben Shaw , Salk Cancer Center , Professor Reuben Shaw , Science Advances , Chien Min Hung , போர்ஶிய லோம்பார்டோ , ரூபன் ஷா , சாள்க் புற்றுநோய் மையம் , ப்ரொஃபெஸர் ரூபன் ஷா , சீன் நிமிடம் தொங்கவிடப்பட்டது ,