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Study Shows New Approach to Target Deadly Form of Prostate Cancer

Study Shows New Approach to Target Deadly Form of Prostate Cancer
goodmenproject.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from goodmenproject.com Daily Mail and Mail on Sunday newspapers.

United States , Peters Nelson , Anna Megdell , Oliviaa Swaim , Ilsa Coleman , Colm Morrissey , Joshij Alumkal , Williamk Storck , Chao Zhang , Archana Sehrawat , Karan Bedi , Aaron Udager , Zhi Duan , Joshi Alumkal , Xiao Ming Wang , Diana Flores , Arvind Rao , Anbarasu Kumaraswamy , Visweswaran Ravikumar , Johnk Lee , Rahul Mannan , Joshuaa Kuleape , Joela Yates , Eva Rodansky , Zheng Xia , Astellas Pharma ,

Overcoming a newly recognized form of resistance to modern prostate cancer drugs

Overcoming a newly recognized form of resistance to modern prostate cancer drugs
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , San Francisco , Sanjay Lakhotia , Chao Zhang , Wayned Kuni , Williamk Storck , Anbarasu Kumaraswamy , Felixy Feng , Evas Rodansky , Duanchen Sun , Xiangnan Guan , Sarah Attwell , Chelsea Jenkins , Himisha Beltran , Rahul Aggarwal , Zheng Xia , Colm Morrissey , Joshi Alumkal , Markp Labrecque , David Sampson , Joshuaa Urrutia , Jonathanz Sexton , Emilym Gesner , Joela Yates , Danielj Coleman , Katherine Welker Leng ,

PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough


PI3K/AKT/mTOR Inhibitors for Prostate Cancer – Finally Hints of a Breakthrough
Published 05 January 2021
Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has been strongly linked with prostate cancer progression and metastatic potential.
1 Loss of the inhibitory phosphatase, PTEN, leading to hyperactivation of PI3K/AKT/mTOR oncogenic signaling, occurs in 40-50% of metastatic castration-resistant prostate cancer.
1,2 Not surprising is the fact that PTEN loss in patients with metastatic castration-resistant prostate cancer is associated with a worse prognosis and less benefit from androgen receptor (AR) blockade.
3 Likewise, PTEN loss and subsequent Akt activation confer radiation ....

United States , Fred Hutchinson Cancer Research Center , University Of Washington , Yunfeng Li , Shunyou Wang , Evany Shi , Nicholast Ingolia , Seema Plaisier , Vivekk Arora , Ratnab Ray , Yu Chen , Ashkan Morim , Houjian Cai , Williame Friedrichs , Bretts Carver , Sarat Chandarlapaty , Merrittp Edlind , Davidp Wood , John Wongvipat , Georgej Netto , Nikolaus Schultz , Suma Raju , Evan Yu , Anuradha Gopalan , Linhm Tran , Matthewr Janes ,