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Worse COVID Illness, Stronger Immunity After?

Worse COVID Illness, Stronger Immunity After?
By Robert Preidt
HealthDay Reporter
WEDNESDAY, Jan. 27, 2021 (HealthDay News) People who ve recovered from severe COVID-19 may have stronger long-term immune protection from reinfection than those with milder illness, researchers report.
They examined blood samples from 39 COVID-19 patients and 10 people who hadn t been exposed to the virus (their blood samples were given pre-pandemic). In all, they analyzed the expression of individual genes of more than 80,000 CD8+ T-cells.
CD8+ T-cells are immune cells that destroy virus-infected host cells, and memory CD8+ T-cells protect the body from reinfection by many types of viruses.
Of the COVID-19 patients, 17 had milder illness and weren t hospitalized, 13 had been hospitalized, and nine ended up in intensive care. The researchers were surprised to find that patients with milder COVID-19 had weaker CD8+ T-cell responses. ....

La Jolla , United States , Christian Ottensmeier , Pandurangan Vijayanand , Jolla Institute For Immunology , Jolla Institute , University Of Liverpool , Healthday News , லா ஜொல்லா , ஒன்றுபட்டது மாநிலங்களில் , பாண்டுரங்கன் விஜயனண்த் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , ஜொல்லா நிறுவனம் , பல்கலைக்கழகம் ஆஃப் லிவர்பூல் ,

Study sheds more light on role played by immune system's T cells against coronavirus

Study sheds more light on role played by immune system s T cells against coronavirus
PTI
Los Angeles |
Updated on
January 22, 2021
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Scientists, including one of Indian-origin, have found that people with severe Covid-19 are left with more of the immune system s protective memory T cells needed for fighting reinfection with the novel coronavirus.
The study, published in the journal Science Immunology, assessed the expression of individual genes of a subset of T cells isolated from both Covid-19 patients and non-exposed donors.
‘Memory’ T cells
Analysing more than 80,000 CD8+ T cells, the scientists, including those from La Jolla Institute of Immunology (LJI) in the US, believe the study is the first to describe these cells that fight the SARS-CoV-2 virus in high resolution detail. ....

Pandurangan Vijayanand , Christianh Ottensmeier , Jolla Institute Of Immunology , Science Immunology , Covid 19 , Memoryt Cells , Cd8t Cells , பாண்டுரங்கன் விஜயனண்த் , ஜொல்லா நிறுவனம் ஆஃப் நோயெதிர்ப்பு , அறிவியல் நோயெதிர்ப்பு ,

A closer look at T cells reveals big differences in mild vs. severe COVID-19 cases

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IMAGE: People with severe COVID-19 manifestations may be left with more of the protective memory T cells needed to fight reinfection.
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Credit: La Jolla Institute for Immunology
LA JOLLA, CA A big question on people s minds these days: how long does immunity to SARS-CoV-2 last following infection?
Now a research team from La Jolla Institute for Immunology (LJI), The University of Liverpool and the University of Southampton has uncovered an interesting clue. Their new study suggests that people with severe COVID-19 cases may be left with more of the protective memory T cells needed to fight reinfection.
The data from this study suggest people with severe COVID-19 cases may have stronger long-term immunity, says study co-leader LJI Professor Pandurangan Vijayanand, M.D., Ph.D. ....

United Kingdom , Pandurangan Vijayanand , Hayley Simon , Vicente Fajardo , Emanuela Pelosi , Christianh Ottensmeier , Serenaj Chee , Anthony Kusnadi , Benjaminj Meckiff , Wessex Clinical Research Network , University Of Southampton , National Institutes Of Health , Williamk Bowes Jr Foundation , Whittaker Foundation , University Of Liverpool , National Institute Of Health Research United Kingdom , Jolla Institute For Immunology , Science Immunology , National Institutes , National Institute , Health Research United , Ciro Ram , ஒன்றுபட்டது கிஂக்டம் , பாண்டுரங்கன் விஜயனண்த் , ஹேலி சிமோன் , விசென்ட் பஜற்தோ ,

Immune Cell Gene Expression Revealed in 3D Maps

Immune Cell Gene Expression Revealed in 3D Maps
Enhancers serve as specific switches that turn on genes in a cell specific manner but it has been difficult to determine which switch is connected to which gene. [Alex Fung]
December 22, 2020
Enhancers serve as specific switches that turn on genes in a cell specific manner but it has been difficult to determine which switch is connected to which gene. [Alex Fung]
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To understand how genes affect human health, researchers need to go beyond variants in the DNA sequence, and dive into the switches, or enhancers, that control when and where a gene is expressed in the body. Now, researchers at La Jolla Institute for Immunology have created 3D maps of how enhancer sequences and genes interact in several types of immune cells. This work advances the understanding of individual risk for diseases from asthma to cancer and even COVID-19. ....

Vivek Chandra , Pandurangan Vijayanand , Jolla Institute For Immunology , Nature Genetics , Immune Cell Expression , விவேக் சந்திரா , பாண்டுரங்கன் விஜயனண்த் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , இயற்கை ஜெநெடிக்ஸ் , நோய் எதிர்ப்பு சக்தி செல் வெளிப்பாடு ,

Novel 3D maps show how genes interact in several types of immune cells

Novel 3D maps show how genes interact in several types of immune cells
The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease.
The difference is within us. We can get infected by the same bacteria or viruses, but the ways our diseases progress can be very different.
Vivek Chandra, Ph.D, Instructor at La Jolla Institute for Immunology
Genetic variations are important, but there s more to the puzzle. To truly understand how genes affect health, researchers need to track down the switches (also called enhancers ) that control when and where a gene is expressed in the body. ....

San Diego , United States , Vivek Chandra , Sourya Bhattacharyya , Pandurangan Vijayanand , Emily Henderson , Vijayanand Laboratory , Institute Leadership , Jolla Institute For Immunology , Instructor At La Jolla Institute For Immunology , Uc San Diego School Of Medicine , Nature Genetics , Diego School , Regulatory Interactome , Postdoctoral Fellow Sourya Bhattacharyya , Immune Cell Expression , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , விவேக் சந்திரா , சூர்யா பட்டாச்சார்யா , பாண்டுரங்கன் விஜயனண்த் , எமிலி ஹென்டர்சன் , விஜயனண்த் ஆய்வகம் , நிறுவனம் தலைமைத்துவம் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , பயிற்றுவிப்பாளர் இல் லா ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு ,