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Team discovers protein crucial for B cell differentiation and antibodies

Team discovers protein crucial for B cell differentiation and antibodies
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

San Diego , United States , Margaret Veselits , Katia Georgopoulos , Zhihong Zhang , Marcusr Clark , Matthew Ellenbogen , Daniela Salgado Figueroa , Sourya Bhattacharyya , Brucea Morgan , Mariko Kashiwagi , Georgopoulos Lab , Jolla Institute For Immunology , Harvard Medical School , May Lab , Massachusetts General Hospital , Georgopoulos Labs , Harvard Medical ,

Novel 3D maps show how genes interact in several types of immune cells


Novel 3D maps show how genes interact in several types of immune cells
The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease.
The difference is within us. We can get infected by the same bacteria or viruses, but the ways our diseases progress can be very different.
Vivek Chandra, Ph.D, Instructor at La Jolla Institute for Immunology
Genetic variations are important, but there s more to the puzzle. To truly understand how genes affect health, researchers need to track down the switches (also called enhancers ) that control when and where a gene is expressed in the body. ....

San Diego , United States , Vivek Chandra , Sourya Bhattacharyya , Pandurangan Vijayanand , Emily Henderson , Vijayanand Laboratory , Institute Leadership , Jolla Institute For Immunology , Instructor At La Jolla Institute For Immunology , Uc San Diego School Of Medicine , Nature Genetics , Diego School , Regulatory Interactome , Postdoctoral Fellow Sourya Bhattacharyya , Immune Cell Expression , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , விவேக் சந்திரா , சூர்யா பட்டாச்சார்யா , பாண்டுரங்கன் விஜயனண்த் , எமிலி ஹென்டர்சன் , விஜயனண்த் ஆய்வகம் , நிறுவனம் தலைமைத்துவம் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , பயிற்றுவிப்பாளர் இல் லா ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு ,

New 3D maps reveal inner workings of immune cell gene expression


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IMAGE: Enhancers serve as specific switches that turn on genes in a cell specific manner but it has been difficult to determine which switch is connected to which gene.
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Credit: Alex Fung
LA JOLLA The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies respond to disease.
The difference is within us, says Vivek Chandra, Ph.D., an instructor at La Jolla Institute for Immunology (LJI). We can get infected by the same bacteria or viruses, but the ways our diseases progress can be very different.
Genetic variations are important, but there s more to the puzzle. To truly understand how genes affect health, researchers need to track down the switches (also called enhancers ) that control when and where a gene is expressed in the body. ....

San Diego , United States , Pandurangan Vijayanand , Mitchell Kronenberg , Pejman Mohammadi , Gregory Seumois , Vivek Chandra , Sourya Bhattacharyya , Bjoern Peters , Stephanie Fotsing , Benjaminj Schmiedel , Austin Crinklaw , Ariel Madrigal , Vijayanand Laboratory , Institute Leadership , Jolla Institute For Immunology , National Institutes Of Health , Williamk Bowes Jr Foundation , Uc San Diego School Of Medicine , Nature Genetics , Diego School , Regulatory Interactome , Postdoctoral Fellow Sourya Bhattacharyya , Immune Cell Expression , National Institutes , சான் டியாகோ ,