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Discovery provides critical clues to why many immunotherapies trigger dangerous side effects

It's not often that a failed clinical trial leads to a scientific breakthrough. When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong. ....

United Kingdom , Pandurangan Vijayanand , Christianh Ottensmeier , Simon Eschweiler , Mitchell Kronenberg , Emily Henderson , Clatterbridge Cancer Centre , Jolla Institute For Immunology , University Of Liverpool , Professor Pandurangan Vijayanand , Chief Scientific Officer Mitchell Kronenberg , B Cell , Ancer Immunotherapy , Clinical Trial , Genomic Sequencing , Immune System ,

LJI researchers discover new genes in CD4+ "helper" T cell subsets

T cells play important roles in helping to fight infections and cancers-;and they can also drive autoimmune diseases. Now researchers at La Jolla Institute for Immunology (LJI) have discovered new genes in CD4+ "helper" T cell subset that are linked to risk of autoimmune diseases. ....

Pandurangan Vijayanand , Benjamin Schmiedel , Jolla Institute For Immunology , Immune Cell Gene Expression , Science Immunology , Ene Expression ,

Once upon BCG vaccine

LA JOLLA A long, long time ago, the BCG vaccine was approved for use against tuberculosis (TB), and it’s still given to infants today. For ....

Kaylin Muskat , Rebecca Kuan , Pandurangan Vijayanand , Jyotirmoy Das , Akul Singhania , Paige Dubelko , Alessandro Sette , Lindestam Arlehamn , Simona Mallal , Elizabethj Phillips , Bjoern Peters , Williamd Chronister , Maria Lerm , Phd Technology , Jolla Institute For Immunology , Murdoch University , National Institutes Of Health , Vanderbilt University , Research Assistant Professor Cecilia Lindestam Arlehamn , National Institutes ,

Study explores connections between COVID-19 severity and gene expression in immune cells

New research shows how genetic variations linked to severe cases of COVID-19 affect our immune cells. ....

Pandurangan Vijayanand , Benjamin Schmiedel , Emily Henderson , Nature Communications , Jolla Institute For Immunology , Host Genetic Initiative , Genetic Initiative , Immune Cell Epigenomes , Ene Expression , Immune System ,

Many cancer patients may need a sequential one-two punch of immunotherapies

Many cancer patients may need a sequential one-two punch of immunotherapies
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United Kingdom , Tilman Sanchez Elsner , Pandurangan Vijayanand , James Clarke , Ioannis Karydis , Aiman Alzetani , Christianh Ottensmeier , Simon Eschweiler , Serenaj Chee , Ramirez Suastegui , Ariel Madrigal , Bharat Panwar , Somaia Elsheikh , Peters Friedmann , Wessex Clinical Research Network , National Institute Of Health Research , National Institutes Of Health , Williamk Bowes Jr Foundation , Whittaker Foundation , University Of Liverpool , Jolla Institute For Immunology , Cancer Research United Kingdom , National Institutes , National Institute , Health Research , Cancer Research United ,