Lynda Blundell s home is full of wonderful memories. The clock her son Phillip made for her hangs on her living room wall, as she dusts dozens of cannon figurines her husband Peter collected over the years.
High insulin levels directly linked to pancreatic cancer. First detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer
A new study from researchers at the University of British Columbia's Faculty of Medicine reveals a direct link between high insulin levels, common among patients with obesity and Type 2 diabetes, and pancreatic cancer.
The first detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer has been published in Cell Metabolism. The research demonstrates that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This overstimulation leads to inflammation that converts these cells into precancerous cells.The researchers say the findings may have implications for other cancers associated with obesity and Type 2 diabetes, where elevated insulin levels may also play a contributing role in disease initiation.