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Stiffness in our tissues causes tension in our cells. Research from the Buck Institute, the University Health Network (University of Toronto), Stanford University, and the University of Alberta shows that stiffness impacts the innate immune system by upping its metabolism. The findings suggest the cellular tension likely sets off an inflammatory loop that contributes to the development of chronic diseases of aging. Publishing in
Cell Reports, Buck Associate Professor Dan Winer, MD, and colleagues present an emerging way of looking at how the immune system functions, possibilities for new immunotherapeutics, and a call for scientists to reconsider the way they do research. ....

Stanford University , United States , Palo Alto , Yi Tao Chan , Evangelos Michelakis , Mainak Chakraborty , Chiara Pastrello , Cynthia Goh , Dan Winer , Los Angeles , Fanta Barrow , Xiangyue Zhang , Megan Lee , Shawn Winer , Edgarg Engleman , Pamelas Ohashi , Aventis Pasteur , Xavier Clemente Casares , Saad Khan , Igor Jurisica , Nicholask Kotoulas , Juan Jovel , Camille Huang , Annie Shrestha , Xaviers Revelo , Masoud Akbari ,