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Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials

Author summary Why was this study done? ➢ Clinicians and researchers depend on the peer-reviewed literature for accurate assessments of drug efficacy and safety, but this depends on whether the outcomes of all trials—negative, as well as positive—are reported transparently. ➢ In an earlier study, using Food and Drug Administration (FDA) review documents as a gold standard, we found that many negative trials had been misreported in the published literature as having positive outcomes or had simply not been published. ➢ Since then, reporting bias has been the subject of additional studies and policy changes, raising the question, Is the antidepressant literature now being reported more transparently? What did the researchers do and find? ➢ Using FDA reviews on 4 newer antidepressants, we identified 30 trials, half with positive, and half with negative, outcomes. ➢ Among the 15 negative trials, 6 were unpublished and 2 others were misre ....

United States , Ilya Ivlev , Aarons Kesselheim , Angelini Pharma , Kathryn Burrows , Sepideh Alavi , Ryan Mckenna , Yusuki Ogawa , Drug Administration , International Committee Of Journal Editors , Oxford Health Biomedical Research Centre , National Institute For Health Research , International Clinical Trials Registry Platform , Drug Administration Amendments Act , Harvard University , Incipit Italian Network For Paediatric Trials , University Of Bern , Oxford Cognitive Health Clinical Research Facility , Thames Valley Applied Research Collaboration , Research Professorship , Drug Administration Amendments , Creative Commons , Supporting Information , Medical Officer , National Institute , Health Research ,

Ahmedabad prepares for Covid-19 third wave, conducts paediatric survey


Ahead of the potential third wave of COVID-19, the Ahmedabad administration has taken up surveillance work and is conducting a pediatric survey to identify the most vulnerable children in order to make timely arrangements for their protection.
Speaking to ANI, Health Officer Sandhya Rathod said, We have started screening children in the age group of 0-5 years. We have 206 teams of ASHA and Anganwadi workers. They are surveying around 250 houses per day.
We are maintaining a separate list of children suffering from malnutrition and other severe diseases. In the case of the third wave, we can reverse quarantine the high-risk group. I have five teams in Sanand with two doctors and a female health worker in each team, she said. ....

Arun Mahesh Babu , Ahmedabad District Development , Women Development , Health Officer Sandhya Rathod , District Development Officer , Primary Education , Neonatal Intensive Care Unit , Paediatric Intensive Care Unit , Covid Third Wave , Hmedabad Covid Third Wave Preparation , Paediatric Trials , Hmedabad Covid Preparation , அருண் மகேஷ் பாபு , அஹமதாபாத் மாவட்டம் வளர்ச்சி , பெண்கள் வளர்ச்சி , மாவட்டம் வளர்ச்சி அதிகாரி , ப்ரைமரீ கல்வி , பிறந்த குழந்தை தீவிர பராமரிப்பு அலகு , குழந்தை தீவிர பராமரிப்பு அலகு ,