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Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials

Author summary Why was this study done? ➢ Clinicians and researchers depend on the peer-reviewed literature for accurate assessments of drug efficacy and safety, but this depends on whether the outcomes of all trials—negative, as well as positive—are reported transparently. ➢ In an earlier study, using Food and Drug Administration (FDA) review documents as a gold standard, we found that many negative trials had been misreported in the published literature as having positive outcomes or had simply not been published. ➢ Since then, reporting bias has been the subject of additional studies and policy changes, raising the question, Is the antidepressant literature now being reported more transparently? What did the researchers do and find? ➢ Using FDA reviews on 4 newer antidepressants, we identified 30 trials, half with positive, and half with negative, outcomes. ➢ Among the 15 negative trials, 6 were unpublished and 2 others were misre ....

United States , Ilya Ivlev , Aarons Kesselheim , Angelini Pharma , Kathryn Burrows , Sepideh Alavi , Ryan Mckenna , Yusuki Ogawa , Drug Administration , International Committee Of Journal Editors , Oxford Health Biomedical Research Centre , National Institute For Health Research , International Clinical Trials Registry Platform , Drug Administration Amendments Act , Harvard University , Incipit Italian Network For Paediatric Trials , University Of Bern , Oxford Cognitive Health Clinical Research Facility , Thames Valley Applied Research Collaboration , Research Professorship , Drug Administration Amendments , Creative Commons , Supporting Information , Medical Officer , National Institute , Health Research ,

Study Points to Best Treatments for Depression in Primary Care

Study Points to Best Treatments for Depression in Primary Care
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United States , Neil Skolnik , Angelini Pharmam , Pim Cuijpers , Psychische Gezondheid , Toyota Motor Corporation , Boehringer Ingelheim , American College Of Physicians , Sidney Kimmel Medical College , European Union , Dutch Ministry Of Defense , Incipit Italian Network For Paediatric Trials , Vrije Universiteit Amsterdam , Hamilton Depression Rating , Meta Analysis Is Still Useful , Clinical Practice Guideline , American College , Fonds Psychische Gezondheid , Civiel Militaire Zorg , Dutch Ministry , Psychological Bulletin , Italian Network , Paediatric Trials , Kyowa Kirin , ஒன்றுபட்டது மாநிலங்களில் , நீல் ச்கொல்நீக் ,