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Vaccine boosts innate immunity in people with

<p><strong>Bacillus Calmette-Gu&eacute;rin (BCG) is one of the world&rsquo;s oldest and most widely used vaccines. It was developed in the early 20<sup>th</sup> century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by Christoph Bock and Mihai Netea found that epigenetic cell states predict whether or not an individual profits from the &ldquo;wake-up call&rdquo; to the innate immune system that is provided by the BCG vaccine. This discovery contributes to the development of future therapeutics that induce protective trained immunity.</strong></p>
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United States , Christoph Bock , Erwin Schr , Mihai Netea , Stefan Bernhardt , Netherlands Royal Academy Of Sciences , Cemm Research Center , University Of Vienna , Christoph Bock Cemm Medical University Of Vienna , Radboud University Medical Center , European Research Council , Mihai Netea Radboud University Medical Center , Department Of Internal Medicine , Prize Of The Austrian Academy Sciences , Research Center , Austrian Academy Of Sciences , European Union Horizon , European Lab For , Infectious Diseases Society Of America , Netherlands Organization For Scientific Research , Austrian Science Fund Special Research Area , Human Cell Atlas Organizing Committee , Method Of Research , Pr Communications , Curie Actions Individual Fellowship , European Union ,

Scientists develop new method for ultra-high-throughput RNA sequencing in single cells

RNA sequencing is a powerful technology for studying cells and diseases. Scientists from the research group of Christoph Bock, principal investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and professor at the Medical University of Vienna, developed a new method for sequencing huge numbers of single cells in an efficient manner. The study has now been published in Nature Methods. ....

Martin Senekowitsch , Daniele Barreca , Paul Datlinger , Christoph Bock , Thomas Krausgruber , Thorina Boenke , Lise Meitner , Broad Institute , Austrian Science Fund , Ludwig Boltzmann Institute For Rare , Grant European Union Horizon , Max Planck Institute For Informatics , Harvard University , Research Program , University Of Vienna Meduni , University Of Vienna , Cemm Research Center , European Lab For , Molecular Medicine , Austrian Academy , Medical University , Nature Methods , Special Research Program , European Union , Max Planck Institute , Biomedical Sequencing Facility ,