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Dabrafenib and Trametinib Plus Navitoclax Meets CR End Point in BRAF V600–mutant Metastatic Melanoma

The combination of dabrafenib and trametinib plus navitoclax generated responses and met the co-primary end point for complete response rate vs historical controls in patients with BRAF V600–mutant metastatic melanoma. ....

United States , Anita Giobbie Hurder , Zeynep Eroglu , Genentech Roche , Boehringer Ingelheim , Department Of Oncologic Sciences , Cutaneous Oncology , Moffitt Cancer Center , Oncologic Sciences , South Florida Morsani College , Asco Annual Meeting , Ctep P9466 ,