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Oncologists Explore Treatment Options in LGSOC, Look Toward Promising Future

Although there are no FDA-approved treatments specifically indicated for low-grade serous ovarian cancer, therapeutic options for these patients are rapidly expanding, with promising new approaches progressing through clinical development. ....

Missouri , United-states , Texas , Houston , Washington-university , Corrs , Davidm-omalley , Premalh-thaker , Shannonn-westin , Onclive-news-network , Department-of-obstetrics

Enfortumab Vedotin/Pembrolizumab Combo, Maintenance Avelumab Continue as Gold Standards in Metastatic Urothelial Cancer

Lance C. Pagliaro, MD, highlights updated data from the JAVELIN Bladder 100 and EV-103 trials in metastatic urothelial carcinoma, discusses their relevance for navigating the expanding treatment armamentarium for this disease, and outlines several future avenues for research. ....

United-states , Minnesota , Mayo-clinic-in-rochester , American , Powlest-sridhar , Lancec-pagliaro , Department-of-oncology , American-urological-association-annual-meeting , Division-of-medical-oncology , Urological-association-annual , Medical-oncology

FDA Grants Priority Review to Mirvetuximab Soravtansine in FRα+ Platinum-Resistant Ovarian Cancer

The FDA has granted priority review to the supplemental biologics license application seeking the conversion of the accelerated approval of mirvetuximab soravtansine-gynx in patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who previously received 1 to 3 lines of systemic treatment to full approval. ....

China , Michael-vasconcelles , European-medicines-agency-acceptance , China-national-medical-products-administration , P-european-medicines-agency , Immunogen-inc , Prescription-drug-user-fee-act , National-medical-products , Mirvetuximab-soravtansine , Elahare , Ovarian-cancer , Platinum-resistant-ovarian-cancer

Retrospective Study Shows Nivolumab Associated With OS Benefit After Nivolumab/Ipilimumab irAEs in Advanced Melanoma

Elizabeth I. Buchbinder, MD, discusses findings from a retrospective study evaluating the resumption of nivolumab maintenance therapy in patients with advanced melanoma who discontinued treatment with the combination of nivolumab and ipilimumab due to immune-related adverse effects. ....

Boston , Massachusetts , United-states , Dana-farber-cancer-institute , Elizabethi-buchbinder , Harvard-medical-school , D , Melanoma , Asco-annual-meeting , Nivolumab , Immune-related-adverse-effects

ImPrint Biomarker Predicts Immunotherapy Response in Patients With HR+/HER2– Breast Cancer

Denise M. Wolf, PhD, discusses the methods used to conduct the I-SPY2 study and the implications that immune biomarkers could have on selecting treatment for patients with hormone receptor–positive, HER2-negative breast cancer in the future. ....

San-francisco , California , United-states , Denisem-wolf , Michaelj-campbell , Department-of-laboratory-medicine , University-of-california , Laboratory-medicine , Cancer-cell , Investigational-device-exemption , Phd