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Research identifies how leukemia develops resistance to first line treatments

Relapses in a common form of leukemia may be preventable following new research which has identified how the cancer develops resistance to first line treatments. ....

Terry Rabbitts , Terry Rabbitt , Constanze Bonifer , Institute Of Cancer , Newcastle University , University Of Birmingham , University Of Virginia , Genomic Sciences , University Of Melbourne , Institute Of Cancer Research , Princess Maxima Centre Of Pediatric , Cancer Research , Princess Maxima Centre , Weatherall Institute , Molecular Medicine University , Acute Myeloid Leukemia , Myeloid Leukemia , Blood Cancer , Ell Death , Drug Discovery , Growth Factor , Medical Research , Transcription Factors ,

Rare variants in the YKT6 gene cause new neurological disorder, study finds

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer. ....

United States , Wendy Chung , Mengqi Ma , Thomas Christian , Thomas Christians , Hugo Bellen , Paula Hertel , Mythily Ganapathi , Department Of Pediatrics At Boston Children Hospital , James Lupski At Baylor College Of Medicine , Dan Duncan Neurological Research Institute , Service Professor At Baylor College Of Medicine , Distinguished Service Professor , Baylor College , Principal Investigator , Texas Children , Boston Children , Columbia University Irving Medical Center , Davut Pehlivan , James Lupski , Baylor Genetics , Saint Thomas Christians , Saint Thomas Christian , Amino Acid , Liver Cancer , Liver Disease ,

Mapping the brain: How cell types and location influence Parkinson's disease

A single-cell spatial transcriptome analysis on murine brain expression in age and disease using a Parkinson's disease. ....

Cell Reports , Uniform Manifold Approximation , Ene Expression , Arkinson 39s Disease , Ibonucleic Acid ,

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Researchers analyzed the toxicity concerns and advancements in mRNA therapeutics, focusing on their cellular toxicity, reactogenicity, and distribution, and discussed the challenges and benefits of mRNA research. ....

Nature Reviews Drug Discovery , Covid 19 , Drug Discovery , N Vitro , Protein Synthesis ,

Gut microbiota: the new frontier in Alzheimer's disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis. ....

Topmicrobialstock Shutterstock , Molecular Medicinejournal , Gene Sequencing , Eurodegenerative Disease , Tau Protein ,