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Unraveling the relationship between obesity-related metabolic dysfunction and endotrophin

With obesity rates projected to continue rising globally, there is an urgent need to understand the intricate mechanisms that contribute to metabolic diseases such as diabetes. ....

Megan Craig , National Research Foundation , Ministry Of Science , Department Of Biological Sciences , Jiyoung Park , Biological Sciences , Professor Park , Insulin Resistance ,

Scientists discover new role for liver tPA in regulating cholesterol levels

Despite advances in treatment for high cholesterol, heart disease remains the leading cause of death in the U.S. Scientists at the Medical College of Wisconsin (MCW) are investigating the role of a form of cholesterol called very-low-density lipoprotein – and their findings may lead to new treatment options in the future. ....

Lily Ramsey , Owen Dai , Centers For Disease , Versiti Blood Research Institute , Cardiovascular Center Atherosclerosis , Drug Administration , College Of Wisconsin , Vascular Biology Program , Medical College , Versiti Blood Research , Poulletier De La Salle , Disease Control , Vascular Biology , Heart Disease , Blood Vessel , Blood Vessels , High Cholesterol ,

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome. ....

Kateryna Kon Shutterstock , Scientific Reports , Lzheimer 39s Disease , N Vivo , Lupus Erythematosus , Multiple Sclerosis , Rheumatoid Arthritis , Systemic Lupus Erythematosus ,

Can air pollution shape adolescent brain development? New study reveals sex-specific effects of PM2.5, NO2, and O3 on white matter microstructure

Researchers investigated the sex-stratified effects of childhood exposure to ambient air pollutants. ....

United States , Tridsanu Thopet Shutterstock , Research Square , World Health Organization , United States Environmental Protection Agency , Brain Cognitive Development , Adolescent Brain Cognitive Development , Air Pollution , Magnetic Resonance Imaging ,

Synergistic winter flounder antimicrobial peptides unveil new path to enhanced bactericidal therapy

The synergistic action of six winter flounder (WF) antimicrobial peptides (AMPs) against bacterial pathogens. ....

United Kingdom , Micheleursi Shutterstock , Avanti Polar Lipids Inc , Cambridge Research Biochemicals , Winter Flounder , Avanti Polar Lipids , Fractional Inhibitory Concentration , Antibiotic Resistance , N Vitro ,