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Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR)

Objective To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care.

Design Two parallel group multicentre phase III randomised placebo controlled trial.

Setting 106 general practices in four UK sites; Bristol, Exeter, Hull, and Keele/North Staffs, August 2013 to October 2015.

Participants 480 adults aged 18 or more years who scored 14 or more on the Beck depression inventory, second revision, fulfilled ICD-10 (international classification of diseases, 10th revision) criteria for depression, and had used an SSRI or SNRI for at least six weeks but were still depressed. 241 were randomised to mirtazapine and 239 to placebo, both given in addition to usual SSRI or SNRI treatment. Participants were stratified by centre and minimised by baseline Beck depression inventory score, sex, and current psychol ....

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Have your say: Is eating cold oatcakes a 'hanging offence'?

Have your say: Is eating cold oatcakes a 'hanging offence'?
stokesentinel.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from stokesentinel.co.uk Daily Mail and Mail on Sunday newspapers.

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Paddy McGuinness says 'it's disgusting' and hits out in x-rated rant

Paddy McGuinness says 'it's disgusting' and hits out in x-rated rant
birminghammail.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from birminghammail.co.uk Daily Mail and Mail on Sunday newspapers.

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Man, 32, arrested after 'hit-and-run' smash off A500 left four hurt

Man, 32, arrested after 'hit-and-run' smash off A500 left four hurt
stokesentinel.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from stokesentinel.co.uk Daily Mail and Mail on Sunday newspapers.

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Driver 'tailgated by 100mph Audi involved in hit-and-run smash'

Driver 'tailgated by 100mph Audi involved in hit-and-run smash'
stokesentinel.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from stokesentinel.co.uk Daily Mail and Mail on Sunday newspapers.

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