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An unexpected, and novel, target for prostate cancer - our biological clock


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PHILADELPHIA - Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It s no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S. With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer - Jefferson Health (SKCC) explored the circadian clock and found an unexpected role for the clock gene CRY-1 in cancer progression. The study was published on January 15th in ....

United States , Yanyun Zhu , Karene Knudsen , Andre Bergman , Karuna Meda , Felixy Feng , Irinaa Vasilevskaya , Matthewj Schiewer , Chrism Mcnair , Jenniferj Mccann , Ayesha Shafi , Nicolas Gordon , Talyas Laufer , Tesam Severson , Saswatin Chand , Emanuela Dylgjeri , Karen Knudsen , Anton Shostak , Felix Feng , Wilbert Zwart , Amyc Mandigo , Michael Brunner , Ayeshaa Shafi , Mohammed Alshalalfa , Peter Gallagher , Nature Communications ,