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Author summary Why was this study done? ➢ The EuroQol-5 dimension (EQ-5D) and SF-36 are questionnaire-based tools that combine measures of physical and mental health into overall quality of life scores. These scores are used in randomised controlled trials of drug treatments to estimate how treatments affect quality of life. These estimates then inform decisions about which treatments should be offered to people with specific conditions. ➢ Multimorbidity, the presence of 2 or more conditions, makes diagnosis and treatment more complex and is associated with worse quality of life in some settings. ➢ People with multimorbidity are underrepresented in clinical trials, and little is known about whether and how multimorbidity changes quality of life in clinical trials. This makes it difficult for clinicians and clinical guideline developers to determine how results from clinical trials should be applied to people with multimorbidity. What did the researchers do and find? ➢ To ....

City Of , United Kingdom , Glasgow City , United States , Davidm Kent , Bruce Guthrie , Jim Lewsey , Elainew Butterly , Emma Mcintosh , Davida Mcallister , Peter Hanlon , Lauriej Hannigan , Nickyj Welton , Francess Mair , Anoopsv Shah , Effectiveness Center , Norwegian Institute Of Public Health , University Of Edinburgh , Bristol Medical School , Population Health Sciences , University Of York , University Of Bristol , Department Of Mental Disorders , Affiliation Usher Institute , University Of Glasgow , Affiliation Population Health Sciences ,