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Two novel biobanks offer investigatory targets for cocaine and oxycodone addiction


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A major hurdle to developing new and effective treatments for drug addiction is better understanding how exactly it manifests itself before, during and after chronic use. In a paper published online in the April 21, 2021 issue of the journal
eNeuro, an international team of researchers led by scientists at University of California San Diego School of Medicine describe the creation of two unique collections of more than 20,000 biological samples collected from laboratory rats before, during and after chronic use of cocaine and oxycodone.
Developed by the Preclinical Addiction Research Consortium, located in the Department of Psychiatry at UC San Diego School of Medicine and at Skaggs School of Pharmacy and Pharmaceutical Sciences, the new cocaine and oxycodone biobanks include samples from 20 different organs, plus urine, blood and feces. ....

San Diego , United States , University Of California San Diego , Apurvas Chitre , Kokila Shankar , Abrahama Palmer , Molly Brennan , Adam Kimbrough , Olivier George , Mckenziej Fannon , Oksana Polesskaya , Bonnie Lin , Lisa Maturin , Lieselot Lg Carrette , Jenni Kononoff , Lani Tieu , Francisco Ramirez Jr , Brent Boomhower , Dana Conlisk , Laurenc Smith , Nathan Velarde , Marsida Kallupi , Centers For Disease , Skaggs School Of Pharmacy , Department Of Psychiatry , Ghent University ,

Hunger cues


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Animals use their sense of smell to navigate the world to find food, sniff out mates and smell danger. But when a hungry animal smells food and a member of the opposite sex at the same time, what makes dinner the more attractive option? Exactly what is it about the odor of food that says, Choose me?
Research by investigators at Harvard Medical School illuminates the neurobiology that underlies food attraction and how hungry mice choose to pay attention to one object in their environment over another.
In their study, published March 3 in
Nature, Stephen Liberles and co-author Nao Horio, identified the pathway that promotes attraction to food odors over other olfactory cues. ....

Stephen Liberles , Mishima Kaiun Memorial Foundation , National Institutes Of Health , Harvard Medical School , Blavatnik Institute , Uehara Memorial Foundation , Howard Hughes Medical Institute , Nao Horio , Howard Hughes Medical , National Institutes , Cell Biology , Medicine Health , Olfactory Taste , மிஷிமா காஉன் நினைவகம் அடித்தளம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , ஹார்வர்ட் மருத்துவ பள்ளி , ஊஎர நினைவகம் அடித்தளம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , ஹோவர்ட் ஹக்ஸ் மருத்துவ , தேசிய நிறுவனங்கள் , செல் உயிரியல் ,

How tangled proteins kill brain cells, promote Alzheimer's, CTE


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Look deep inside the brain of someone with Alzheimer s disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you ll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.
Such conditions, collectively known as tauopathies strike scores of people across the globe, with Alzheimer s alone affecting six million people in the United States.
But more than a century after German psychiatrist Alois Alzheimer discovered tau tangles, scientists still have much to learn about them.
A University of Colorado Boulder study, published this week in the journal
Neuron, shows for the first time that tau aggregates gobble up RNA, or ribonucleic acid, inside cells and interfere with an integral mechanism called splicing, by which cells ultimately produce needed proteins. ....

United States , Alois Alzheimer , Evan Lester , Troy Parker , Scientist Training Program , A University Of Colorado Boulder , University Of Colorado Anschutz Medical Campus , Biofrontiers Institute , Cognition Center , Colorado Boulder , Medical Scientist Training Program , Colorado Anschutz Medical Campus , Cell Biology , Molecular Biology , Medicine Health , Alzheimers Disease , Parkinsons Disease , Pharmaceutical Science , Pharmaceutical Chemistry , ஒன்றுபட்டது மாநிலங்களில் , அலோயிஸ் முதுமறதி , எவன் லெஸ்டர் , ராய் பார்க்கர் , விஞ்ஞானி பயிற்சி ப்ரோக்ர்யாம் , பல்கலைக்கழகம் ஆஃப் கொலராடோ அண்சச்சுட்ஸ் மருத்துவ வளாகம் , அறிவாற்றல் மையம் ,

Neural plasticity depends on this long noncoding RNA's journey from nucleus to synapse


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IMAGE: Synaptic activation promotes a signaling cascade that results in the expression of long noncoding RNA, ADEPTR. It s quickly transported along dendrites to synapses, where it acts on proteins involved in.
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Credit: Credit: Jenna Wingfield and Yibo Zhao of the Puthanveettil lab at Scripps Research in Jupiter, Florida.
JUPITER, FL Making memories involves more than seeing friends or taking photos. The brain constantly adapts to new information and stores memories by building connections among neurons, called synapses. How neurons do this reaching out arm-like dendrites to communicate with other neurons requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery. ....

United States , Yosef Avchalumov , Supriya Swarnkar , Ryohei Yasuda , Eddie Grinman , Sathyanarayanan Puthanveettil , Isabel Espadas , Yoshihisa Nakahata , Scripps Research , Max Planck Florida Institute For Neuroscience , Max Planck Florida Institute , Cell Biology , Molecular Biology , ஒன்றுபட்டது மாநிலங்களில் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி ,

New type of cell contributes to increased understanding of ALS


Credit: Ulf Sirborn
The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study, which is published in
Nature Medicine, has potential implications for earlier diagnoses and future treatments.
ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. ....

City Of , United Kingdom , Nathan Skene , Gohren Antequera , Albert Ludolph , Jan Veldink , Aylin Domaniku , Elena Rodriguez Vieitez , Jennie Olofsson , Sevval Aksoylu , Jonathand Gilthorpe , Anna Szczepi , Mathias Uhl , Karolinska Institutet , Sebastiana Lewandowski , Eva Hedlund , Hermieneke Vergunst Bosch , Koen Poesen , Peter Nilsson , Manuela Lehmann , Eleonora Aronica , Sebastian Lewandowski , Philip Van Damme , Roberta Harris , Caroline Mijnsbergen , Lwaki Ebarasi ,