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New type of cell contributes to increased understanding of ALS


Credit: Ulf Sirborn
The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study, which is published in
Nature Medicine, has potential implications for earlier diagnoses and future treatments.
ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. ....

City Of , United Kingdom , Nathan Skene , Gohren Antequera , Albert Ludolph , Jan Veldink , Aylin Domaniku , Elena Rodriguez Vieitez , Jennie Olofsson , Sevval Aksoylu , Jonathand Gilthorpe , Anna Szczepi , Mathias Uhl , Karolinska Institutet , Sebastiana Lewandowski , Eva Hedlund , Hermieneke Vergunst Bosch , Koen Poesen , Peter Nilsson , Manuela Lehmann , Eleonora Aronica , Sebastian Lewandowski , Philip Van Damme , Roberta Harris , Caroline Mijnsbergen , Lwaki Ebarasi ,

Genetic differences important in Alzheimer's diagnosis


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IMAGE: Schematic illustration of how brain imaging resp. cerebrospinal fluid measures the accumulation of amyloid protein.
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Credit: The research team.
The two used methods for detecting amyloid pathology in Alzheimer s disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet in Sweden have found genetic explanations for the differences. The study is published in
Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs.
Alzheimer s disease is the most common dementia disease and leads to gradual memory loss and premature death. Approximately 120,000 people in Sweden have Alzheimer s and there are approximately 50 million people worldwide. According to Hjärnfonden, the number will increase by 70 percent in 50 years, partly because we are living longer and longer. ....

Karolinska Institutet , Arianna Sala , Agneta Nordberg , Elena Rodriguez Vieitez , Dementia Foundation , Department Of Neurobiology , Brain Foundation , University Of Li , Foundation For Strategic Research , Technical University Of Munich , Swedish Research Council , European Union Innovative Medicines Initiative , Alzheimer Foundation , Salute San Raffaele University , Ake Wiberg Foundation , Caring Sciences , Molecular Psychiatry , Vita Salute San Raffaele University , Technical University , Strategic Research , அரியன்னா சலா , முதுமை அடித்தளம் , துறை ஆஃப் நரம்பியல் , மூளை அடித்தளம் , பல்கலைக்கழகம் ஆஃப் லி , அடித்தளம் க்கு மூலோபாய ஆராய்ச்சி ,

Genetic differences important for Alzheimer's diagnosis


Date Time
Genetic differences important for Alzheimer’s diagnosis
The two used methods for detecting amyloid pathology in Alzheimer’s disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs.
Arianna Sala, currently a post-doctoral fellow at the University of Liège, Belgium and Technical University of Munich, and first author. Photo: Francesco Ciurlo.
Alzheimer’s disease is the most common dementia disease and leads to gradual memory loss and premature death. Approximately 120,000 people in Sweden have Alzheimer’s and there are approximately 50 million people worldwide. According to Hjärnfonden, the number will increase by 70 percent in 50 years, partly because we are living longer and l ....

Karolinska Institutet , Arianna Sala , Elena Rodriguez Vieitez , Francesco Ciurlo , Agneta Nordberg , Amit Kumar , Dementia Foundation , Wiberg Foundation , Department Of Neurobiology , Brain Foundation , University Of Li , Foundation For Strategic Research , Technical University Of Munich , Swedish Research Council , European Union Innovative Medicines Initiative , Alzheimer Foundation , Salute San Raffaele University , Caring Sciences , Molecular Psychiatry , Technical University , Vita Salute San Raffaele University , Strategic Research , அரியன்னா சலா , அமித் குமார் , முதுமை அடித்தளம் , விபேர்க் அடித்தளம் ,