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Novel gene-editing strategy harnesses an unusual protective ability to eliminate HIV-1 infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses. ....

San Francisco , United States , Thomasj Cradick , Conradry Cruz , Shuren Liao , Kamel Khalili , Shohreh Amini , Laurah Carnell , Catherinem Bollard , James Dressman , Chong Liu , Danielle Ellis , Daniellek Sohaii , Magda Florez , Carlos Barrero , Triciah Burdo , Aanand Mehta , Jennifer Gordon , Rafal Kaminski , Stephane Grauzam , Neuroaids Center , Department Of Microbiology , Department Of Cell , School Of Pharmacy , National Institutes Of Health , Temple University ,

Dual CRISPR Gene Editing Strategy Could Eliminate HIV-1 and Enable Cure

Researchers suggest approach may eventually lead to permanent elimination of HIV-1 and protect from reinfection. ....

Rafal Kaminski , Triciah Burdo , Laurah Carnell , Kamel Khalili , Lewis Katz School Of Medicine , Department Of Microbiology , Neuroaids Center , Lewis Katz School , Temple University , Molecular Therapy , Nucleic Acids , Gene Editing ,

New Study: Gene Therapy Can Effectively Eliminate HIV Infection

Researchers from Temple University and UNMC collaborate in a study recently published in the journal Proceedings of the National Academy of Sciences. Gene-editing therapy targeting both HIV-1, the virus responsible for AIDS, and CCR5, the co-receptor assisting viral entry into cells, has been de ....

United States , University Of Nebraska Medical Center , Shohreh Amini , Maurizio Caocci , Triciah Burdo , Rafal Kaminski , R Lee Mosley , Benson Edagwa , Saumi Mathews , Lili Guo , Santhi Gorantla , Brady Sillman , Laurah Carnell , Chen Zhang , Emiko Waight , Howard Gendelman , Larisay Poluektova , Howarde Gendelman , Kamel Khalili , Shuren Liao Sruthi Sravanam , Chong Liu , Pietro Mancuso , Tricia Burdo , Rahsan Sariyer , Proceedings Of The National Academy Sciences , Department Of Microbiology ,

HIV eliminated in mice in new study

The possibility of using gene-editing to eliminate HIV is growing stronger, according to a group of researchers who have successfully combined gene-editing with antiretroviral drugs to cure animals of HIV a feat they have now pulled off more than once. ....

United States , University Of Nebraska Medical Center , Howarde Gendelman , Kamel Khalili , Temple University , Department Of Pharmacology , World Health Organization , Neuroaids Center , Lewis Katz School Of Medicine , Proceedings Of The National Academy Sciences , National Academy , World Health , Experiential Neuroscience , Nebraska Medical Center , Lewis Katz School ,

Chances of eliminating HIV infection increased by novel dual gene-editing approach

Chances of eliminating HIV infection increased by novel dual gene-editing approach
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United States , Pietro Mancuso , Benson Edagwa , Saumi Mathews , Triciah Burdo , Laurah Carnell , Larisay Poluektova , Rafal Kaminski , Howarde Gendelman , Kamel Khalili , Maurizio Caocci , Rahsan Sariyer , Emiko Waight , Brady Sillman , Chong Liu , R Lee Mosley , Santhi Gorantla , Shohreh Amini , Shuren Liao , Lili Guo , Chen Zhang Sruthi Sravanam , Department Of Microbiology , Neuroaids Center , Katz School Of Medicine , Lewis Katz School Of Medicine , Department Of Pharmacology ,