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Aggressive RBC Transfusions No Help in Extremely Small Babies


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Extremely small newborns tolerated a restrictive red blood cell transfusion strategy for anemia in the multicenter TOP trial.
Around 2 years of age, infants had similar rates of either death or survival but with neurodevelopmental impairment (i.e., cognitive delay, cerebral palsy, hearing, or vision loss) whether they had been randomized to higher or lower hemoglobin thresholds for transfusion in the neonatal intensive care unit (NICU) shortly after birth (50.1% vs 49.8%, adjusted RR 1.00, 95% CI 0.92-1.10).
The individual components of death (16.2% vs 15.0%) and neurodevelopmental impairment (39.6% vs 40.3%) were no different between the higher and lower hemoglobin strategies, respectively, according to a group led by Haresh Kirpalani, MD, MSc, of Children s Hospital of Philadelphia. ....

Stanford University , United States , Nicole Lou , Haresh Kirpalani , Human Development , Stanford University School Of Medicine , New England Journal , Lance Prince , Stanford University School , Lucile Packard Children , Hospital Stanford , Medpage Today , Neonatal Research Network , Eunice Kennedy Shriver National Institute , Child Health , England Journal , Englj Med , ஸ்டான்போர்ட் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , நிக்கோல் லூ , ஹரேஷ் கிற்பளநி , மனிதன் வளர்ச்சி , ஸ்டான்போர்ட் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , புதியது இங்கிலாந்து இதழ் , லான்ஸ் ப்ரிந்ஸ் , ஸ்டான்போர்ட் பல்கலைக்கழகம் பள்ளி ,