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Frontiers | Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching

Abstract Objectives: Non-alcoholic fatty liver disease (NAFLD) greatly affects cardiovascular disease, but evidence on the associations between NAFLD and markers of aortic calcification is limited. We aim to evaluate the association between NAFLD and aortic calcification in a cohort of Chinese adults using propensity score-matching (PSM) analysis. Methods: This prospective cohort study involved adults who underwent health-screening examinations from 2009 to 2016. NAFLD was diagnosed by abdominal ultrasonography at baseline, and aortic calcification was identified using a VCT LightSpeed 64 scanner. Analyses included Cox proportional-hazards regression analysis and PSM with predefined covariates (age, gender, marital and smoking status, and use of lipid-lowering drugs) to achieve a 1:1 balanced cohort. Results: Of 6,047 eligible participants, 2,729 (45.13%) were diagnosed with NAFLD at baseline, with a median age of 49.0 years [interquartile range: 44.0–55.0]. We selected 2,339 pairs o ....

United States , Xiao Tang Shan , Nei Mongol , Mario Masarone , Vasc Pharmacol , Henryl Wymer , J Vasc Endovasc , Al Rifai , Gastroenterol Hepatol , Arterioscler Thromb Vasc , Van Poucke , Association Of Nonalcoholic Fatty Liver Disease , Natural Public Welfare Fund Of Zhejiang Province , Jinan University , Shenzhen Nanshan Centre For Chronic Disease , American College Of Gastroenterology , Key Laboratory Of Diagnosis , Artery Risk Development In Young Adults , Key Projects Of Ningbo Public Welfare Fund , American Gastroenterological Association , Technology Foundation Of Zhejiang Province , Association Between Liver Fat , Samsung Medical Center Health Promotion , National Age , Risk Factors For Development Of Intimal Hyperplasia , Health Science ,